지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
Sequencing Analysis of Ligand Binding Domain of Aryl Hydrocarbon Receptor which is a Dioxin Sensitive Gene in the Ornamental Birds
Sequencing Analysis of Ligand Binding Domain of Aryl Hydrocarbon Receptor which is a Dioxin Sensitive Gene in the Ornamental Birds
이용수
Sequencing Analysis of Ligand Binding Domain of Aryl Hydrocarbon Receptor which is a Dioxin Sensitive Gene in the Ornamental Birds
초록· 키워드
오류제보하기
Toxicity of dioxins and dioxin like compounds (DLCs) is mainly mediated by aryl hydrocarbon receptor (AHR) which is a cytoplasmic transcription factor and highly conserved in animal taxa. Birds are exposed to various environmental contaminants of DLCs and accumulated the high levels of these chemicals in their tissues or organs. Birds have multiple AHR isoforms, such as AHR1 and AHR2. In our previous research, avian AHR1 is dominant isoform to determine the dioxin sensitivity and the two critical amino acid sites (324<SUP>th</SUP> and 380<SUP>th</SUP> site) in its ligand binding domain (LBD) are important to induce the different sensitivity. In this study, to investigate the dioxin sensitivity in ornamental birds, we analyzed the amino acid sequences of AHR LBDs in the four avian species, Budgerigar, Domestic canary, Bengalese finch and Zebra finch. AHR LBD sequences isolated from 4 avian species showed two types of AHR1 LBD which might be predicted in high sensitivity (Ile<SUP>324th</SUP>_Ser<SUP>380th</SUP>, I-S type) and moderate sensitivity (Ile<SUP>324th</SUP>_Ala<SUP>380th</SUP>, I-A type). Although sample numbers are not enough, I-A moderate type is prominently shown in these ornamental avian species than other types such as I-S or V-A types (Val<SUP>324th</SUP>_Ala<SUP>380th</SUP>).
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (19)
참고문헌 신청
[학술지(정기간행물)] - Bird D. M. / 1983 / Synergistic effects of Aroclor 1254, mirex on the semen characteristics of American kestrels / Archives of Environmental Contamination, Toxicology 12 (6) : 633 ~ 640
[학술지(정기간행물)] - Burbach K. M. / 1992 / Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor / Proceedings of the National Academy of Sciences of the USA 89 (17) : 8185 ~ 8189
[학술지(정기간행물)] - Ema M. / 1994 / Human arylhydrocarbon receptor : functional expression, chromosomal assignment to 7p21 / J Biochemistry 116 (4) : 845 ~ 851
[학술지(정기간행물)] - Farmahin R. / 2012 / Sequence, in vitro function of chicken, ring-necked pheasant, , Japanese quail AHR1 predict in vivo sensitivity to dioxins / Environmental Science & Technology 46 (5) : 2967 ~ 2975
[학술지(정기간행물)] - Fujisawa N. / 2012 / Molecular evidence predicts aryl hydrocarbon receptor ligand insensitivity in the peregrine falcon(Falco peregrines) / European Journal of Wildlife Research 58 (1) : 167 ~ 175
[학술지(정기간행물)] - Burbach K. M. / 1992 / Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor / Proceedings of the National Academy of Sciences of the USA 89 (17) : 8185 ~ 8189
[학술지(정기간행물)] - Ema M. / 1994 / Human arylhydrocarbon receptor : functional expression, chromosomal assignment to 7p21 / J Biochemistry 116 (4) : 845 ~ 851
[학술지(정기간행물)] - Farmahin R. / 2012 / Sequence, in vitro function of chicken, ring-necked pheasant, , Japanese quail AHR1 predict in vivo sensitivity to dioxins / Environmental Science & Technology 46 (5) : 2967 ~ 2975
[학술지(정기간행물)] - Fujisawa N. / 2012 / Molecular evidence predicts aryl hydrocarbon receptor ligand insensitivity in the peregrine falcon(Falco peregrines) / European Journal of Wildlife Research 58 (1) : 167 ~ 175
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UCI(KEPA) : I410-ECN-0101-2016-482-002239195