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Sequencing Analysis of Ligand Binding Domain of Aryl Hydrocarbon Receptor which is a Dioxin Sensitive Gene in the Ornamental Birds
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논문 기본 정보

Type
Academic journal
Author
Hae-Jeong Park (Kyung Hee University) Ji-Hee Hwang (Kyung Hee University) Jin-Young Park (National Institute of Environmental Research) Eun-Young Kim (Kyung Hee University)
Journal
The Ornithological Society Of Korea The Korean Journal of Ornithology Vol.22 No.2 KCI Accredited Journals
Published
2015.12
Pages
1 - 8 (8page)

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Method
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Sequencing Analysis of Ligand Binding Domain of Aryl Hydrocarbon Receptor which is a Dioxin Sensitive Gene in the Ornamental Birds
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Toxicity of dioxins and dioxin like compounds (DLCs) is mainly mediated by aryl hydrocarbon receptor (AHR) which is a cytoplasmic transcription factor and highly conserved in animal taxa. Birds are exposed to various environmental contaminants of DLCs and accumulated the high levels of these chemicals in their tissues or organs. Birds have multiple AHR isoforms, such as AHR1 and AHR2. In our previous research, avian AHR1 is dominant isoform to determine the dioxin sensitivity and the two critical amino acid sites (324<SUP>th</SUP> and 380<SUP>th</SUP> site) in its ligand binding domain (LBD) are important to induce the different sensitivity. In this study, to investigate the dioxin sensitivity in ornamental birds, we analyzed the amino acid sequences of AHR LBDs in the four avian species, Budgerigar, Domestic canary, Bengalese finch and Zebra finch. AHR LBD sequences isolated from 4 avian species showed two types of AHR1 LBD which might be predicted in high sensitivity (Ile<SUP>324th</SUP>_Ser<SUP>380th</SUP>, I-S type) and moderate sensitivity (Ile<SUP>324th</SUP>_Ala<SUP>380th</SUP>, I-A type). Although sample numbers are not enough, I-A moderate type is prominently shown in these ornamental avian species than other types such as I-S or V-A types (Val<SUP>324th</SUP>_Ala<SUP>380th</SUP>).
#aryl hydrocarbon receptor #dioxin sensitivity #birds #ligand binding domain

Contents

Introduction
Materials and Methods
Results
Discussion
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References (19)

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[학술지(정기간행물)] - Bird D. M. / 1983 / Synergistic effects of Aroclor 1254, mirex on the semen characteristics of American kestrels / Archives of Environmental Contamination, Toxicology 12 (6) : 633 ~ 640 google schola [학술지(정기간행물)] - Burbach K. M. / 1992 / Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor / Proceedings of the National Academy of Sciences of the USA 89 (17) : 8185 ~ 8189 google schola [학술지(정기간행물)] - Ema M. / 1994 / Human arylhydrocarbon receptor : functional expression, chromosomal assignment to 7p21 / J Biochemistry 116 (4) : 845 ~ 851 google schola [학술지(정기간행물)] - Farmahin R. / 2012 / Sequence, in vitro function of chicken, ring-necked pheasant, , Japanese quail AHR1 predict in vivo sensitivity to dioxins / Environmental Science & Technology 46 (5) : 2967 ~ 2975 google schola [학술지(정기간행물)] - Fujisawa N. / 2012 / Molecular evidence predicts aryl hydrocarbon receptor ligand insensitivity in the peregrine falcon(Falco peregrines) / European Journal of Wildlife Research 58 (1) : 167 ~ 175 google schola

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UCI(KEPA) : I410-ECN-0101-2016-482-002239195