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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 310 - 317 (8page)
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Cluster of differentiation 1 (CD1) is a family of cell-surface glycoproteins that present lipid antigens to T cells. Humans have five CD1 isoforms. CD1a is distinguished by the small volume of its antigen-binding groove and its stunted A′ pocket, its high and exclusive expression on Langerhans cells, and its localization in the early endosomal and recycling intracellular trafficking compartments. Its ligands originate from self or foreign sources. There are three modes by which the T-cell receptors of CD1a-restricted T cells interact with the CD1a:lipid complex: they bind to both the CD1a surface and the antigen or to only CD1a itself, which activates the T cell, or they are unable to bind because of bulky motifs protruding from the antigen-binding groove, which might inhibit autoreactive T-cell activation. Recently, several studies have shown that by producing TH2 or TH17 cytokines, CD1arestricted T cells contribute to inflammatory skin disorders, including atopic dermatitis, psoriasis, allergic contact dermatitis, and wasp/bee venom allergy. They may also participate in other diseases, including pulmonary disorders and cancer, because CD1a-expressing dendritic cells are also located in non-skin tissues. In this mini-review, we discuss the current knowledge regarding the biology of CD1a-reactive T cells and their potential roles in disease.
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참고문헌 (73)
참고문헌 신청
Agea, E. / 2005 / Human CD1-restricted T cell recognition of lipids from pollens / J. Exp. Med 202:295~308
Akbari, O. / 2003 / Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity / Nat. Med 9:582~588
Angenieux, C. / 2000 / Characterization of CD1e, a third type of CD1molecule expressed in dendritic cells / J. Biol. Chem 275:37757~37764
Baharom, F. / 2016 / Dendritic cells and monocytes with distinct inflammatory responses reside in lung mucosa of healthy humans / J. Immunol 196:4498~4509
Balato, A. / 2012 / IL-33 is secreted by psoriatic keratinocytes and induces pro-inflammatory cytokines via keratinocyte and mast cell activation / Exp. Dermatol 21:892~894
Akbari, O. / 2003 / Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity / Nat. Med 9:582~588
Angenieux, C. / 2000 / Characterization of CD1e, a third type of CD1molecule expressed in dendritic cells / J. Biol. Chem 275:37757~37764
Baharom, F. / 2016 / Dendritic cells and monocytes with distinct inflammatory responses reside in lung mucosa of healthy humans / J. Immunol 196:4498~4509
Balato, A. / 2012 / IL-33 is secreted by psoriatic keratinocytes and induces pro-inflammatory cytokines via keratinocyte and mast cell activation / Exp. Dermatol 21:892~894
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