지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.1
- 수록면
- 97 - 108 (12page)
- DOI
- 10.1007/s13258-021-01173-1
이용수
초록· 키워드
오류제보하기
Background
Long non-coding RNAs (lncRNAs) are widely involved in gene transcription regulation and which act as epigenetic modifiers in many diseases.
Objective
To determine whether lncRNAs are involved in ischemic stroke (IS), we analyzed the expression profile of lncRNAs and mRNAs in IS.
Methods
RNA sequencing was performed on the blood of three pairs of IS patients and healthy controls. Differential expression analysis was used to identify differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs). Based on the co-expression relationships between lncRNA and mRNA, a series of bioinformatics analysis including GO and KEGG enrichment analysis and PPI analysis, were conducted to predict the function of lncRNA.
Results
RNA sequencing produced a total of 5 DElncRNAs and 144 DEmRNAs. Influenza A pathway and Herpes simplex infection pathway were the most significant pathways. EP300 and NFKB1 were the most important target proteins, and Human leucocyte antigen (HLA) family were the key genes in IS.
Conclusions
Analysis of this study revealed that dysregulated lncRNAs in IS may lead to IS by affecting the immune and inflammation system.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
식물의 긴비암호화 RNA들의 생물학적 기능
생명과학회지
2016 .09
-
Roles of Oncogenic Long Non-coding RNAs in Cancer Development
Genomics & informatics
2018 .01
-
Bioinformatic and integrated analysis identifies an lncRNA–miRNA–mRNA interaction mechanism in gastric adenocarcinoma
Genes & Genomics
2021 .01
-
Genome wide identification and functional prediction of long non-coding RNAs in Brassica rapa
Genes & Genomics
2016 .01
-
RNA sequencing reveals lncRNA-mediated non-mendelian inheritance of feather growth change in chickens
Genes & Genomics
2022 .11
-
LncRNA expression profile analysis of Mg2+-induced osteogenesis by RNA-seq and bioinformatics
Genes & Genomics
2021 .11
-
LncRNA Gm2044 highly expresses in spermatocyte and inhibits Utf1 translation by interacting with Utf1 mRNA
Genes & Genomics
2018 .01
-
Prognostic Value of an Immune Long Non-Coding RNA Signature in Liver Hepatocellular Carcinoma
Journal of Microbiology and Biotechnology
2024 .04
-
Silence of LncRNA GAS5Protects Cardiomyocytes H9c2 against Hypoxic Injury via Sponging miR-142-5p
Molecules and Cells
2019 .01
-
Circulating HOTAIR LncRNA Is Potentially Up-regulated in Coronary Artery Disease
Genomics & informatics
2018 .01
-
Whole transcriptome mapping reveals the lncRNA regulatory network of TFP5 treatment in diabetic nephropathy
Genes & Genomics
2024 .05
-
Ovarian transcriptome profiles associated with sexual maturation in Pacific abalone (Haliotis discus hannai)
Genes & Genomics
2020 .01
-
The association of long non-coding RNA in the prognosis of oral squamous cell carcinoma
Genes & Genomics
2022 .03
-
Discovery of high-expressing lncRNA-derived sORFs as potential tumor-associated antigens in hepatocellular carcinoma
Genes & Genomics
2024 .09
-
Analysis of Whole Transcriptome Sequencing Data: Workflow and Software
Genomics & informatics
2015 .01
-
Incredible RNA: Dual Functions of Coding and Noncoding
Molecules and Cells
2016 .05
-
LncRNA CRNDE Promotes the Progression of B-cell Precursor Acute Lymphoblastic Leukemia by Targeting the miR-345-5p/CREB Axis
Molecules and Cells
2020 .01
-
The NuA3 HAT Antagonizes the Rpd3S and Rpd3L HDACs to Optimize mRNA and lncRNA Expression Dynamics
한국미생물학회 학술대회논문집
2020 .10
-
Sequencing CURLY LEAF-associated RNAs in Arabidopsis revealed prevalent intergenic RNAs from the nuclear mitochondrial sequence
Molecules and Cells
2024 .01
-
Expression of lncRNA NEAT1 in endometriosis and its biological functions in ectopic endometrial cells as mediated via miR-124-3p
Genes & Genomics
2022 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0