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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 47 - 53 (7page)
- DOI
- https://doi.org/10.13041/jpvm.2018.42.2.47
이용수
초록· 키워드
오류제보하기
We investigated the effects of two Brucella proteins expressed in a pMAL expression system, RocF and EF-Ts, as subunit vaccines on immune modulation and protective efficacy using a mouse model. Mice vaccinated with MBP-RocF and MBP-EF-Ts displayed increased production of TNF, IFN-, MCP-1, IL-10 and IL-6, and TNF and MCP-1, respectively. Furthermore, mice vaccinated with MBP-EF-Ts showed decreased induction of IFN- and Th2-related cytokines, IL-10 and IL-6. Higher proportions of CD4+ and CD8+ T cells were observed in the blood of mice vaccinated with MBP-RocF than in the PBS-vaccinated group, although the increases were not significant. Furthermore, significantly reduced Brucella proliferation in the spleens of the MBP-RocF and MBP-EF-Ts groups were observed, but inflammation of these organs was not attenuated. Overall, these results indicate that RocF and EF-Ts could be potential subunit vaccine candidates against animal brucellosis.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Berger A / 2000 / Th1 and Th2 responses: what are they? / BMJ 321:424
Crasta OR / 2008 / Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes / PLoS One 3:e2193
Demirdag K / 2003 / Serum cytokine levels in patients with acute brucellosis and their relation to the traditional inflammatory markers / FEMS Immunol Med Microbiol 39:149~153
Deshmane SL / 2009 / Monocyte chemoattractant protein-1 (MCP-1): an overview / J Interferon Cytokine Res 29:313~326
Dienz O / 2009 / The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by $CD4^{+}$ T cells / J Exp Med 206:69~78
Crasta OR / 2008 / Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes / PLoS One 3:e2193
Demirdag K / 2003 / Serum cytokine levels in patients with acute brucellosis and their relation to the traditional inflammatory markers / FEMS Immunol Med Microbiol 39:149~153
Deshmane SL / 2009 / Monocyte chemoattractant protein-1 (MCP-1): an overview / J Interferon Cytokine Res 29:313~326
Dienz O / 2009 / The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by
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