지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제3호
- 발행연도
- 2017.5
- 수록면
- 301 - 308 (8page)
이용수
초록· 키워드
오류제보하기
27-Hydroxycholesterol induces differentiation of monocytic cells into mature dendritic cells, mDCs. In the current study we sought to determine roles of the PI3K and the ERK pathways in the 27OHChol-induced differentiation.
Up-regulation of mDC-specific markers like CD80, CD83 and CD88 induced by stimulation with 27OHChol was significantly reduced in the presence of LY294002, an inhibitor of PI3K, and U0126, an inhibitor of ERK. Surface expression of MHC class I and II molecules elevated by 27OHChol was decreased to basal levels in the presence of the inhibitors. Treatment with LY294002 or U0126 resulted in recovery of endocytic activity which was reduced by 27OHChol. CD197 expression and cell adherence enhanced by 27OHChol were attenuated in the presence of the inhibitors.
Transcription and surface expression of CD molecules involved in atherosclerosis such as CD105, CD137 and CD166 were also significantly decreased by treatment with LY294002 and U0126. These results mean that the PI3K and the ERK signaling pathways are necessary for differentiation of monocytic cells into mDCs and involved in over-expression of atherosclerosis-associated molecules in response to 27OHChol.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Brown AJ / 1999 / Oxysterols and atherosclerosis / Atherosclerosis 142:1~28
Berliner JA / 1995 / Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics / Circulation 91:2488~2496
Kim SM / 2014 / 27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1lymphocytes / Toxicol Appl Pharmacol 274:462~470
Kim SM / 2013 / 27-Hydroxycholesterol induces recruitment of monocytic cells by enhancing CCL2 production / Biochem Biophys Res Commun 442:159~164
Son Y / 2013 / Oxysterols induce transition of monocytic cells to phenotypically mature dendritic cell-like cells / Biochem Biophys Res Commun 438:161~168
Berliner JA / 1995 / Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics / Circulation 91:2488~2496
Kim SM / 2014 / 27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1lymphocytes / Toxicol Appl Pharmacol 274:462~470
Kim SM / 2013 / 27-Hydroxycholesterol induces recruitment of monocytic cells by enhancing CCL2 production / Biochem Biophys Res Commun 442:159~164
Son Y / 2013 / Oxysterols induce transition of monocytic cells to phenotypically mature dendritic cell-like cells / Biochem Biophys Res Commun 438:161~168
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Diclofenac Inhibits 27-hydroxycholesterol-induced Differentiation of Monocytic Cells into Mature Dendritic Cells
Immune Network
2017 .06
-
Inhibitory Effects of Methanol Extract from Nardostachys chinensis on 27-hydroxycholesterol-induced Differentiation of Monocytic Cells
Natural Product Sciences
2017 .12
-
7α-Hydroxycholesterol Elicits TLR6-Mediated Expression of IL-23 in Monocytic Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
The role of 27-hydroxycholesterol in meta-inflammation
The Korean Journal of Physiology & Pharmacology
2024 .03
-
Glucocorticoids Impair the 7α-Hydroxycholesterol-Enhanced Innate Immune Response
Immune Network
2023 .10
-
CD5 Expression Dynamically Changes During the Differentiation of Human CD8+ T Cells Predicting Clinical Response to Immunotherapy
Immune Network
2023 .08
-
Reblastatins Inhibit Phenotypic Changes of Monocytes/Macrophages in a Milieu Rich in 27-Hydroxycholesterol
Immune Network
2020 .04
-
Extrinsic Acquisition of CD80 by Antigen-Specific CD8⁺ T Cells Regulates Their Recall Immune Responses to Acute Viral Infection
Immune Network
2019 .08
-
27-Hydroxycholesterol induces macrophage gene expression via LXR-dependent and -independent mechanisms
The Korean Journal of Physiology & Pharmacology
2021 .01
-
The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer
Immune Network
2023 .10
-
Two Distinct Subsets Are Identified from the Peritoneal Myeloid Mononuclear Cells Expressing both CD11c and CD115
Immune Network
2019 .06
-
Vascular and immune cell network in the pathogenesis of atherosclerosis
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Leukemia propagating cells in Philadelphia chromosome-positive ALL: a resistant phenotype with an adverse prognosis
Blood Research
2018 .01
-
Suppression of CD81 promotes bladder cancer cell invasion through increased matrix metalloproteinase expression via extracellular signal-regulated kinase phosphorylation
Investigative and Clinical Urology
2019 .01
-
Prognostic Significance of CD109 Expression in Patients with Ovarian Epithelial Cancer
Journal of Pathology and Translational Medicine
2019 .01
-
T-Cells Modified with CD70 as an Alternative Cellular Vaccine for Antitumor Immunity
Cancer Research and Treatment
2020 .01
-
Effect of IL-4 on the Development and Function of Memory-like CD8 T Cells in the Peripheral Lymphoid Tissues
Immune Network
2016 .04
-
Effector Memory CD8+ and CD4+ T Cell Immunity Associated with Metabolic Syndrome in Obese Children
Pediatric Gastroenterology, Hepatology & Nutrition
2021 .01
-
mTOR Signaling Combined with Cancer Stem Cell Markers as a Survival Predictor in Stage II Colorectal Cancer
Yonsei Medical Journal
2020 .01
-
Stem Cell Markers Predict the Response to Sorafenib in Patients with Hepatocellular Carcinoma
Gut and Liver
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0