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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 572 - 578 (7page)
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Purpose: Wnt and mammalian target of rapamycin (mTOR) are major molecular signaling pathways associated with the development and progression of tumor, as well as the maintenance and proliferation of cancer stem cells (CSCs), in colorectal cancer (CRC). Identifying patients at risk of poor prognosis is important to determining whether to add adjuvant treatment in stage II CRC and thus improve survival. In the present study, we evaluated the prognostic value of Wnt, mTOR, and CSC markers as survival predictors in stage II CRC. Materials and Methods: We identified 148 cases of stage II CRC and acquired their tumor tissue. Tissue microarrays for immunohistochemical staining were constructed, and the expressions of CD166, CD44, EphB2, β-catenin, pS6 were evaluated using immunohistochemical staining. Results: The expressions of CD166 (p=0.045) and pS6 (p=0.045) and co-expression of pS6/CD166 (p=0.005), pS6/CD44 (p=0.042), and pS6/CD44/CD166 (p=0.013) were negatively correlated with cancer-specific survival. Cox proportional hazard analysis showed the combination of CD166/pS6 [hazard ratio, 9.42; 95% confidence interval, 2.36–37.59; p=0.002] to be the most significant predictor related with decreased cancer-specific survival. In addition, co-expression of CD44/CD166 (p=0.017), CD166/β-catenin (p=0.036), CD44/β-catenin (p=0.001), and CD44/CD166/β-catenin (p=0.001) were significant factors associated with liver metastasis. Conclusion: Specific combinations of CSC markers and β-catenin/mTOR signaling could be a significant predictor of poor survival in stage II CRC.
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참고문헌 (39)
참고문헌 신청
Fedyanin M / 2017 / Role of stem cells in colorectal cancer progression and prognostic and predictive characteristics of stem cell markers in colorectal cancer / Curr Stem Cell Res Ther 12:19~30
Reya T / 2001 / Stem cells, cancer, and cancer stem cells / Nature 414:105~111
Lugli A / 2010 / Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer / Br J Cancer 103:382~390
Jing F / 2015 / Colon cancer stem cell markers CD44 and CD133 in patients with colorectal cancer and synchronous hepatic metastases / Int J Oncol 46:1582~1588
Horst D / 2009 / Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166in colorectal cancer / Cancer Invest 27:844~850
Reya T / 2001 / Stem cells, cancer, and cancer stem cells / Nature 414:105~111
Lugli A / 2010 / Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer / Br J Cancer 103:382~390
Jing F / 2015 / Colon cancer stem cell markers CD44 and CD133 in patients with colorectal cancer and synchronous hepatic metastases / Int J Oncol 46:1582~1588
Horst D / 2009 / Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166in colorectal cancer / Cancer Invest 27:844~850
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