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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제2호
- 발행연도
- 2021.1
- 수록면
- 111 - 118 (8page)
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27-Hydroxycholesterol (27OHChol) exhibits agonistic activity for liver X receptors (LXRs). To determine roles of the LXR agonistic activity in macrophage gene expression, we investigated the effects of LXR inhibition on the 27OHChol-induced genes. Treatment of human THP-1 cells with GSK 2033, a potent cell-active LXR antagonist, results in complete inhibition in the transcription of LXR target genes (such as LXRα and ABCA1) induced by 27OHChol or a synthetic LXR ligand TO 901317. Whereas expression of CCL2 and CCL4 remains unaffected by GSK 2033, TNF-α expression is further induced and 27OHChol-induced CCL3 and CXCL8 genes are suppressed at both the transcriptional and protein translation levels in the presence of GSK 2033. This LXR antagonist downregulates transcript levels and surface expression of CD163 and CD206 and suppresses the transcription of CD14, CD80, and CD86 genes without downregulating their surface levels. GSK 2033 alone had no effect on the basal expression levels of the aforementioned genes. Collectively, these results indicate that LXR inhibition leads to differential regulation of 27-hydroxycholesterolinduced genes in macrophages. We propose that 27OHChol induces gene expression and modulates macrophage functions via LXR-dependent and -independent mechanisms
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참고문헌 (29)
참고문헌 신청
Schroepfer GJ Jr / 2000 / Oxysterols : modulators of cholesterol metabolism and other processes / Physiol Rev 80:361~554
Brown AJ / 1999 / Oxysterols and atherosclerosis / Atherosclerosis 142:1~28
Iuliano L / 2011 / Pathways of cholesterol oxidation via non-enzymatic mechanisms / Chem Phys Lipids 164:457~468
Carpenter KL / 1995 / Lipids and oxidised lipids in human atherosclerotic lesions at different stages of development / Biochim Biophys Acta 1256:141~150
Garcia-Cruset S / 2001 / Oxysterol profiles of normal human arteries, fatty streaks and advanced lesions / Free Radic Res 35:31~41
Brown AJ / 1999 / Oxysterols and atherosclerosis / Atherosclerosis 142:1~28
Iuliano L / 2011 / Pathways of cholesterol oxidation via non-enzymatic mechanisms / Chem Phys Lipids 164:457~468
Carpenter KL / 1995 / Lipids and oxidised lipids in human atherosclerotic lesions at different stages of development / Biochim Biophys Acta 1256:141~150
Garcia-Cruset S / 2001 / Oxysterol profiles of normal human arteries, fatty streaks and advanced lesions / Free Radic Res 35:31~41
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