지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.4
- 수록면
- 126 - 133 (8page)
이용수
초록· 키워드
오류제보하기
Unlike conventional T cells, innate CD8 T cells develop a memory-like phenotype in the thymus and immediately respond upon antigen stimulation, similar to memory T cells. The development of innate CD8 T cells in the thymus is known to require IL-4, which upregulates Eomesodermin (Eomes). These features are similar to that of virtual memory CD8 T cells and IL-4-induced memory-like CD8 T cells generated in the peripheral tissues. However, the relationship between these cell types has not been clearly documented. In the present study, IL-4-induced memory-like CD8 T cells generated in the peripheral tissues were compared with innate CD8 T cells in terms of phenotype and function. When an IL-4/anti-IL-4 antibody complex (IL-4C) was injected into C57BL/6 mice daily for 7 days, the Eomes<SUP>hi </SUP>CXCR3<SUP>＋</SUP> CD8 T cell population was markedly increased in the peripheral lymphoid organs and blood. These cells were generated from naïve CD8 T cells or accumulated via the expansion of pre-existing CD44<SUP>hi</SUP>CXCR3<SUP>＋</SUP> CD8 T cells. Initially, the majority of these CXCR3<SUP>＋</SUP> CD8 T cells expressed low levels of CD44, which was followed by the conversion to the CD44<SUP>hi</SUP> phenotype. This conversion was associated with the acquisition of enhanced effector function. After discontinuation of IL-4C treatment, Eomes expression levels gradually decreased in CXCR3<SUP>＋</SUP> CD8 T cells. Taken together, the results of this study demonstrate that IL-4-induced memory-like CD8 T cells generated in the peripheral lymphoid tissues are phenotypically and functionally similar to the innate CD8 T cells generated in the thymus.
목차
NTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
Berg, L. J. 2007. Signalling through TEC kinases regulates conventional versus innate CD8 ＋ T-cell development. Nat. Rev. Immunol. 7: 479-485.
Veillette, A., Z. Dong, and S. Latour. 2007. Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes. Immunity 27: 698-710.
Lee, Y. J., S. C. Jameson, and K. A. Hogquist. 2011. Alternative memory in the CD8 T cell lineage. Trends Immunol. 32: 50-56.
Atherly, L. O., J. A. Lucas, M. Felices, C. C. Yin, S. L. Reiner, and L. J. Berg. 2006. The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8 ＋ T cells. Immunity 25: 79-91.
Broussard, C., C. Fleischacker, R. Horai, M. Chetana, A. M. Venegas, L. L. Sharp, S. M. Hedrick, B. J. Fowlkes, and P. L. Schwartzberg. 2006. Altered development of CD8 ＋ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity 25: 93-104.
Veillette, A., Z. Dong, and S. Latour. 2007. Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes. Immunity 27: 698-710.
Lee, Y. J., S. C. Jameson, and K. A. Hogquist. 2011. Alternative memory in the CD8 T cell lineage. Trends Immunol. 32: 50-56.
Atherly, L. O., J. A. Lucas, M. Felices, C. C. Yin, S. L. Reiner, and L. J. Berg. 2006. The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8 ＋ T cells. Immunity 25: 79-91.
Broussard, C., C. Fleischacker, R. Horai, M. Chetana, A. M. Venegas, L. L. Sharp, S. M. Hedrick, B. J. Fowlkes, and P. L. Schwartzberg. 2006. Altered development of CD8 ＋ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity 25: 93-104.
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Extrinsic Acquisition of CD80 by Antigen-Specific CD8⁺ T Cells Regulates Their Recall Immune Responses to Acute Viral Infection
Immune Network
2019 .08
-
The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer
Immune Network
2023 .10
-
CD5 Expression Dynamically Changes During the Differentiation of Human CD8+ T Cells Predicting Clinical Response to Immunotherapy
Immune Network
2023 .08
-
Two Distinct Subsets Are Identified from the Peritoneal Myeloid Mononuclear Cells Expressing both CD11c and CD115
Immune Network
2019 .06
-
The Roles of CCR7 for the Homing of Memory CD8+ T Cells into Their Survival Niches
Immune Network
2020 .06
-
T-Cells Modified with CD70 as an Alternative Cellular Vaccine for Antitumor Immunity
Cancer Research and Treatment
2020 .01
-
Innate Immunological Function of Bystander CD4 T Cells in Autoimmunity
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Changes in serum levels of lipopolysaccharides and CD26 in patients with Crohn’s disease
Intestinal research
2017 .01
-
Effector Memory CD8+ and CD4+ T Cell Immunity Associated with Metabolic Syndrome in Obese Children
Pediatric Gastroenterology, Hepatology & Nutrition
2021 .01
-
Leukemia propagating cells in Philadelphia chromosome-positive ALL: a resistant phenotype with an adverse prognosis
Blood Research
2018 .01
-
Re-defining T-Cell Exhaustion: Subset, Function, and Regulation
Immune Network
2020 .02
-
Effect of Peripheral Blood CD4 + CD25 + Regulatory T Cell on Postoperative Immunotherapy for Patients with Renal Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Cluster Containing More Than 20 CD3-Positive Cells in Bone Marrow Biopsy Is a Candidate Prognostic Indicator in Peripheral T-Cell Lymphoma, Not Otherwise Specified
Annals of Laboratory Medicine
2019 .01
-
Canine regulatory T cells expressing CD4+and CD25+ are proliferated by interleukin-2 cytokine
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Unusual CD4+CD28- T Cells and Their Pathogenic Role in Chronic Inflammatory Disorders
Immune Network
2016 .12
-
Ovalbumin으로 유발된 천식 동물모델에서 GGX의 효과
대한한방내과학회지
2023 .06
-
杏仁 분획물이 Th2 cytokine 발현과 NC/Nga mouse의아토피 피부염에 미치는 영향
대한한방소아과학회지
2016 .01
-
CD80CD86 deficiency disrupts regulator T cell homeostasis and induces autoimmune alopecia
한국실험동물학회 학술발표대회 논문집
2016 .08
-
CD8-dependent Tumor Growth Inhibition by Tumor Cells Genetically Modified with 4-1BBL
대한의생명과학회지
2021 .12
-
Absence of Correlation between Changes in the Number of Endothelial Progenitor Cell Subsets
Korean Circulation Journal
2015 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
Early results with the Mutaf technique : a novel offmidline approach in pilonidal sinus surgery
Musa Zo
,
lu
,
İb
외 6명
Annals of Surgical Treatment and Research
2016
.05
고속도로 공공디자인 가이드라인의 도입효과 분석
주신하
,
김경인
Archives of Design Research
2016
.05
중소기업의 경영 특성에 따른 디자인경영활동의 선정
이동규
,
남기영
,
정경원
Archives of Design Research
2016
.05
이용자 경로 기반 비정형 공간의 정보안내 체계 연구 : DDP를 중심으로
이상현
,
오병근
,
황수홍
Archives of Design Research
2016
.05
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-511-002817831