지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 179 - 185 (7page)
이용수
초록· 키워드
오류제보하기
We investigated whether diclofenac could influence the development of antigen-presenting cells in an oxygenated cholesterol-rich environment by determining its effects on the 27-hydroxycholesterol (27OHChol)-induced differentiation of monocytic cells into mature dendritic cells (mDCs). Treatment of human THP-1 monocytic cells with diclofenac antagonized the effects of 27OHChol by attenuating dendrite formation and cell attachment and promoting endocytic function. Diclofenac inhibited the transcription and surface expression of the mDC markers of CD80, CD83, and CD88, and reduced the 27OHChol-induced elevation of surface levels of MHC class I and II molecules to the basal levels in a dose-dependent manner. It also reduced the expression of CD197, a molecule involved in DC homing and migration. These results indicate that diclofenac inhibits the differentiation of monocytic cells into mDCs, thereby potentially modulating adaptive immune responses in a milieu rich in cholesterol oxidation products.
목차
INTRODUCTION
RESULTS
MATERIALS AND METHODS
DISCUSSION
REFERENCES
참고문헌 (26)
참고문헌 신청
Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9: 271-296.
Zhou, L. J., and T. F. Tedder. 1996. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. Proc. Natl. Acad. Sci. U. S. A. 93: 2588-2592.
Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179: 1109-1118.
Lyakh, L. A., G. K. Koski, W. Telford, R. E. Gress, P. A. Cohen, and N. R. Rice. 2000. Bacterial lipopolysaccharide, TNFalpha, and calcium ionophore under serum-free conditions promote rapid dendritic cell-like differentiation in CD14+ monocytes through distinct pathways that activate NK-kappa B. J. Immunol. 165: 3647-3655.
Berges, C., C. Naujokat, S. Tinapp, H. Wieczorek, A. Hoh, M. Sadeghi, G. Opelz, and V. Daniel. 2005. A cell line model for the differentiation of human dendritic cells. Biochem. Biophys. Res. Commun. 333: 896-907.
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
PI3K and ERK signaling pathways are involved in differentiation of monocytic cells induced by 27-hydroxycholesterol
The Korean Journal of Physiology & Pharmacology
2017 .05
-
Inhibitory Effects of Methanol Extract from Nardostachys chinensis on 27-hydroxycholesterol-induced Differentiation of Monocytic Cells
Natural Product Sciences
2017 .12
-
7α-Hydroxycholesterol Elicits TLR6-Mediated Expression of IL-23 in Monocytic Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
Glucocorticoids Impair the 7α-Hydroxycholesterol-Enhanced Innate Immune Response
Immune Network
2023 .10
-
The role of 27-hydroxycholesterol in meta-inflammation
The Korean Journal of Physiology & Pharmacology
2024 .03
-
Reblastatins Inhibit Phenotypic Changes of Monocytes/Macrophages in a Milieu Rich in 27-Hydroxycholesterol
Immune Network
2020 .04
-
Regulation of Th2 Cell Immunity by Dendritic Cells
Immune Network
2016 .02
-
CD5 Expression Dynamically Changes During the Differentiation of Human CD8+ T Cells Predicting Clinical Response to Immunotherapy
Immune Network
2023 .08
-
The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer
Immune Network
2023 .10
-
Vascular and immune cell network in the pathogenesis of atherosclerosis
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Extrinsic Acquisition of CD80 by Antigen-Specific CD8⁺ T Cells Regulates Their Recall Immune Responses to Acute Viral Infection
Immune Network
2019 .08
-
T-Cells Modified with CD70 as an Alternative Cellular Vaccine for Antitumor Immunity
Cancer Research and Treatment
2020 .01
-
Tumor-derived CD4+CD25+ Tregs Inhibit the Maturation and Antigen-Presenting Function of Dendritic Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
27-Hydroxycholesterol induces macrophage gene expression via LXR-dependent and -independent mechanisms
The Korean Journal of Physiology & Pharmacology
2021 .01
-
Induction of CD4⁺ Regulatory and Polarized Effector/helper T Cells by Dendritic Cells
Immune Network
2016 .02
-
Re-defining T-Cell Exhaustion: Subset, Function, and Regulation
Immune Network
2020 .02
-
Heterogeneity of Islet Cells during Embryogenesis and Differentiation
Diabetes and Metabolism Journal
2023 .03
-
Th17 Cell and Inflammatory Infiltrate Interactions in Cutaneous Leishmaniasis: Unraveling Immunopathogenic Mechanisms
Immune Network
2024 .04
-
Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
Parasites, Hosts and Diseases
2016 .10
-
Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes
Immune Network
2017 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-517-000885553