지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.8
- 수록면
- 32 - 44 (13page)
이용수
초록· 키워드
오류제보하기
CD80 is mainly expressed on Ag-presenting cells (APCs) as a costimulatory molecule but is also detected on T cells. However, the origin and physiological role of CD80 on CD8⁺ T cells remain unclear. In the present study, we demonstrated that effector and memory CD8⁺ T cells, but not naïve CD8⁺ T cells, displayed CD80 molecules on their surfaces after acute lymphocytic choriomeningitis virus infection. Using adoptive transfer of CD80-knockout (KO) CD8⁺ T cells into a wild type or CD80-KO recipient, we demonstrated that the effector CD8⁺ T cells displayed CD80 by both intrinsic expression and extrinsic acquisition, while memory CD8⁺ T cells displayed CD80 only by extrinsic acquisition. Interestingly, the extrinsic acquisition of CD80 by CD8⁺ T cells was observed only in the lymphoid organs but not in the periphery, indicating the trogocytosis of CD80 molecules via interaction between CD8⁺ T cells and APCs. We compared the recall immune responses by memory CD8⁺ T cells that either extrinsically acquired CD80 or were deficient in CD80, and found that CD80, presented by memory CD8⁺ T cells, played a role in limiting their expansion and IL-2 production upon exposure to secondary challenge. Our study presents the in vivo dynamics of the extrinsic acquisition of CD80 by Ag-specific CD8⁺ T cells and its role in the regulation of recall immune responses in memory CD8⁺ T cells.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
Kaech SM / 2012 / Transcriptional control of effector and memory CD8+ T cell differentiation / Nat Rev Immunol 12:749~761
Baaten BJ / 2012 / Regulation of antigen-experienced T cells: lessons from the quintessential memory marker CD44 / Front Immunol 3:23
White JT / 2017 / Antigen-inexperienced memory CD8+ T cells: where they come from and why we need them / Nat Rev Immunol 17:391~400
Riond J / 2007 / Capture of membrane components via trogocytosis occurs in vivo during both dendritic cells and target cells encounter by CD8(+) T cells / Scand J Immunol 66:441~450
Rosenits K / 2010 / T cells acquire cell surface determinants of APC via in vivo trogocytosis during viral infections / Eur J Immunol 40:3450~3457
Baaten BJ / 2012 / Regulation of antigen-experienced T cells: lessons from the quintessential memory marker CD44 / Front Immunol 3:23
White JT / 2017 / Antigen-inexperienced memory CD8+ T cells: where they come from and why we need them / Nat Rev Immunol 17:391~400
Riond J / 2007 / Capture of membrane components via trogocytosis occurs in vivo during both dendritic cells and target cells encounter by CD8(+) T cells / Scand J Immunol 66:441~450
Rosenits K / 2010 / T cells acquire cell surface determinants of APC via in vivo trogocytosis during viral infections / Eur J Immunol 40:3450~3457
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer
Immune Network
2023 .10
-
CD5 Expression Dynamically Changes During the Differentiation of Human CD8+ T Cells Predicting Clinical Response to Immunotherapy
Immune Network
2023 .08
-
Two Distinct Subsets Are Identified from the Peritoneal Myeloid Mononuclear Cells Expressing both CD11c and CD115
Immune Network
2019 .06
-
Effect of IL-4 on the Development and Function of Memory-like CD8 T Cells in the Peripheral Lymphoid Tissues
Immune Network
2016 .04
-
Leukemia propagating cells in Philadelphia chromosome-positive ALL: a resistant phenotype with an adverse prognosis
Blood Research
2018 .01
-
Effector Memory CD8+ and CD4+ T Cell Immunity Associated with Metabolic Syndrome in Obese Children
Pediatric Gastroenterology, Hepatology & Nutrition
2021 .01
-
T-Cells Modified with CD70 as an Alternative Cellular Vaccine for Antitumor Immunity
Cancer Research and Treatment
2020 .01
-
Effect of Peripheral Blood CD4 + CD25 + Regulatory T Cell on Postoperative Immunotherapy for Patients with Renal Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Canine regulatory T cells expressing CD4+and CD25+ are proliferated by interleukin-2 cytokine
한국실험동물학회 학술발표대회 논문집
2018 .01
-
The Roles of CCR7 for the Homing of Memory CD8+ T Cells into Their Survival Niches
Immune Network
2020 .06
-
CD9 Expression in Colorectal Carcinomas and Its Prognostic Significance
Journal of Pathology and Translational Medicine
2016 .01
-
Re-defining T-Cell Exhaustion: Subset, Function, and Regulation
Immune Network
2020 .02
-
Changes in serum levels of lipopolysaccharides and CD26 in patients with Crohn’s disease
Intestinal research
2017 .01
-
Prognostic Significance of CD109 Expression in Patients with Ovarian Epithelial Cancer
Journal of Pathology and Translational Medicine
2019 .01
-
CD80CD86 deficiency disrupts regulator T cell homeostasis and induces autoimmune alopecia
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Unusual CD4+CD28- T Cells and Their Pathogenic Role in Chronic Inflammatory Disorders
Immune Network
2016 .12
-
Beyond the Role of CD55 as a Complement Component
Immune Network
2018 .02
-
Cluster Containing More Than 20 CD3-Positive Cells in Bone Marrow Biopsy Is a Candidate Prognostic Indicator in Peripheral T-Cell Lymphoma, Not Otherwise Specified
Annals of Laboratory Medicine
2019 .01
-
Characterization of Human Dental Pulp Cells from Supernumerary Teeth by Using Flow Cytometry Analysis
대한소아치과학회지
2019 .01
-
Ovalbumin으로 유발된 천식 동물모델에서 GGX의 효과
대한한방내과학회지
2023 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2019-517-001220127