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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 756 - 762 (7page)
- DOI
- 10.3349/ymj.2017.58.4.756
이용수
초록· 키워드
오류제보하기
Purpose: Insulin resistance (IR) has an important role in the development of non-alcoholic steatohepatitis (NASH). We aimed to analyze the association between liver histopathology and IR in pediatric patients with NASH.
Materials and Methods: In 24 children with non-alcoholic fatty liver disease (NAFLD), we investigated whether the hepatic pathologiccharacteristics have relations with following three biochemical indices; IR index including homeostasis model assessment of IR (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), and insulin sensitivity indices-free fatty acid (ISI-FFA).
Results: Among 24 patients, 16 (66.6%) had a high NAFLD activity score (NAS), which is diagnostic of NASH. Higher serum triglyceridelevel was significantly correlated with a high NAS. Higher steatosis grades were significantly associated with low insulin sensitivity (p=0.023). In addition, severe lobular inflammation was associated with higher IR: HOMA-IR (p=0.014) and QUICKI (p=0.023). Severe fibrosis correlated with low insulin sensitivity and high IR indexes: ISI-FFA (p=0.049), HOMA-IR (p=0.028), and QUICKI (p=0.007).
Conclusion: Patients with high IR had more severe lobular inflammation and hepatic fibrosis. Analyses of biochemical and endocrineparameters can be applied to determine the severity of the hepatic pathologic status in patients with NASH, especially in children who cannot undergo a liver biopsy.
목차
등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
오경원 / 2008 / 한국 소아청소년의 비만 유병률 추이: 1997년과 2005년 비교 / Korean Journal of Pediatrics 51(9):950~955
Geoffrey C. Farrell / 2012 / NASH is an Infl ammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications / Gut and Liver 6(2):149~171
Watanabe S / 2015 / Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis / J Gastroenterol 50:364~377
Angulo P / 2002 / Nonalcoholic fatty liver disease / N Engl J Med 346:1221~1231
Brunt EM / 1999 / Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions / Am J Gastroenterol 94:2467~2474
Geoffrey C. Farrell / 2012 / NASH is an Infl ammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications / Gut and Liver 6(2):149~171
Watanabe S / 2015 / Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis / J Gastroenterol 50:364~377
Angulo P / 2002 / Nonalcoholic fatty liver disease / N Engl J Med 346:1221~1231
Brunt EM / 1999 / Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions / Am J Gastroenterol 94:2467~2474
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