메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
배지철 (성균관대학교) Lauren A. Beste (University of Washington USA) Kristina M. Utzschneider (University of Washington USA)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.37 No.3
발행연도
2022.6
수록면
455 - 465 (11page)
DOI
https://doi.org/10.3803/EnM.2022.1434

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background: We aimed to investigate the association of hepatic steatosis with liver fibrosis and to assess the interactive effects ofhepatic steatosis and insulin resistance on liver fibrosis in a nationally representative sample of United States adults. Methods: We conducted a cross-sectional analysis using data from National Health and Nutrition Examination Survey 2017 to2018, which for the first time included transient elastography to assess liver stiffness and hepatic steatosis. We evaluated the association between hepatic steatosis (using controlled attenuation parameter [CAP]) and clinically significant liver fibrosis (defined as liverstiffness ≥7.5 kPa) using logistic regression with an interaction term for hepatic steatosis and insulin resistance (defined as homeostatic model assessment of insulin resistance ≥3.0). Results: Among adults undergoing transient elastography (n=2,023), 45.9% had moderate or greater hepatic steatosis and 11.3%had clinically significant liver fibrosis. After adjustment for demographic and metabolic factors, the odds of significant liver fibrosisincreased as CAP score rose (odds ratio, 1.35 per standard deviation increment; 95% confidence interval, 1.11 to 1.64). We detecteda significant interaction effect between CAP score and insulin resistance on the probability of significant liver fibrosis (P=0.016 forinteraction). The probability of significant liver fibrosis increased in the presence of insulin resistance with increasing CAP score,while those without insulin resistance had low probability of significant liver fibrosis, even with high CAP scores. Conclusion: Individuals with hepatic steatosis had higher odds of fibrosis when insulin resistance was present. Our findings emphasize the importance of the metabolic aspects of the disease on fibrosis risk and suggest a need to better identify patients with metabolic associated fatty liver disease.

목차

등록된 정보가 없습니다.

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0