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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,761 - 1,767 (7page)
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초록· 키워드
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Insulin resistance (IR) plays a significant role in the development and progression of non-alcoholic fatty liver disease (NAFLD). However, the natural course of insulin sensitivity under NAFLD remained unclear. Accordingly, this study was designed to investigate the effect of NAFLD on insulin resistance. A total of 20,628 Korean men without homeostasis model assessment of insulin resistance (HOMA-IR < 2.7) were followed-up for 5 years. They were serially checked for HOMA-IR to monitor the development of IR (HOMA-IR ≥ 2.7). The incidence rate of IR increased according to the degree of NAFLD (normal: 11.6%, mild: 28.8%, moderate to severe: 40.5%, P < 0.001). Cox proportional hazards model showed that HRs (95% CI) for IR increased proportionally to the degree of NAFLD (mild: 1.19 [1.02–1.39], moderate to severe: 1.32 [1.08–1.57]). IR was more potentially associated with the more progressive NAFLD than normal and milder state. In addition, NAFLD was the independent risk factor of the development of IR. These results suggest the potential availability of NAFLD as a predictor of IR.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Ruhl CE / 2003 / Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States / Gastroenterology 124:71~79
Pagano G / 2002 / Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association / Hepatology 35:367~372
Sanyal AJ / 2001 / Nonalcoholic steatohepatitis : association of insulin resistance and mitochondrial abnormalities / Gastroenterology 120:1183~1192
Grundy SM / 2005 / Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement / Circulation 112:2735~2752
Angulo P / 2002 / Nonalcoholic fatty liver disease / N Engl J Med 346:1221~1231
Pagano G / 2002 / Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association / Hepatology 35:367~372
Sanyal AJ / 2001 / Nonalcoholic steatohepatitis : association of insulin resistance and mitochondrial abnormalities / Gastroenterology 120:1183~1192
Grundy SM / 2005 / Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement / Circulation 112:2735~2752
Angulo P / 2002 / Nonalcoholic fatty liver disease / N Engl J Med 346:1221~1231
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