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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제18권 제3호
- 발행연도
- 2015.1
- 수록면
- 168 - 174 (7page)
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Purpose: Recent studies have suggested that decreased serum potassium level may contribute to various metabolic disorders in adult patients including nonalcoholic fatty liver disease (NAFLD). We aimed to study the correlation between serum potassium levels and the histologic severity of NAFLD in children. Methods: Pediatric patients with biopsy-proven NAFLD were included in this study. Demographic, clinical, and histo-pathological data were obtained. Multivariable logistic regression analysis was used to assess whether potassium levels are associated with the presence of nonalcoholic steatohepatitis (NASH) or fibrosis after adjusting for possible confounders. A p-value ＜0.05 was considered statistically significant. Results: Among 125 biopsies, 49.6% (62) had evidence of NASH while 66.4% (83) had some degree of fibrosis (stage 1-3). Mean serum potassium was significantly lower in NASH group as compared to non-NASH group (4.4±0.42mmoL/L vs. 4.8±0.21, p＜0.001). Higher potassium level had negative correlation with presence of steatosis, balloon-ing, lobular inflammation, fibrosis and NAFLD activity score (p＜0.05). On multivariable analysis and after adjusting for the metabolic syndrome and insulin resistance, higher potassium level was significantly associated with lower likelihood of having a histological diagnosis of NASH on biopsy (odds ratio [OR], 0.12; 95% confidence interval [95% CI], 0.05-0.28; p＜0.001). Similarly, the likelihood of having fibrosis decreases by 76% for every 0.5 mmoL/L increase in potassium (OR ,0.24; 95% CI, 0.11-0.54; p＜0.001).Conclusion: Our study shows an inverse relationship between serum potassium levels and the presence of ag-gressive disease (NASH and fibrosis) in children with NAFLD.
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참고문헌 (23)
참고문헌 신청
Alkhouri N / 2009 / Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal / Expert Rev Gastroenterol Hepatol 3 : 445 ~ 451
Asrih M / 2013 / Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance / J Endocrinol 218 : R25 ~ 36
Azadbakht L / 2005 / Beneficial effects of a dietary approaches to stop hypertension eating plan on features of the metabolic syndrome / Diabetes Care 28 : 2823 ~ 2831
Boney CM / 2005 / Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus / Pediatrics 115 : e290 ~ 296
Cole TJ / 2000 / Establishing a standard definition for child overweight and obesity worldwide: international survey / BMJ 320 : 1240 ~ 1243
Asrih M / 2013 / Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance / J Endocrinol 218 : R25 ~ 36
Azadbakht L / 2005 / Beneficial effects of a dietary approaches to stop hypertension eating plan on features of the metabolic syndrome / Diabetes Care 28 : 2823 ~ 2831
Boney CM / 2005 / Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus / Pediatrics 115 : e290 ~ 296
Cole TJ / 2000 / Establishing a standard definition for child overweight and obesity worldwide: international survey / BMJ 320 : 1240 ~ 1243
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