지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.6
- 수록면
- 147 - 158 (12page)
이용수
초록· 키워드
오류제보하기
The liver lies at the intersection of multiple metabolic pathways and consequently plays a central role in lipid metabolism. Pathological disturbances in hepatic lipid metabolism are characteristic of chronic metabolic diseases, such as obesity-mediated insulin resistance, which can result in nonalcoholic fatty liver disease (NAFLD). Tissue damage induced in NAFLD activates and recruits liver-resident and non-resident immune cells, resulting in nonalcoholic steatohepatitis (NASH). Importantly, NASH is associated with an increased risk of significant clinical sequelae such as cirrhosis, cardiovascular diseases, and malignancies. In this review, we describe the immunopathogenesis of NASH by defining the known functions of immune cells in the progression and resolution of disease.
목차
INTRODUCTION
HEPATIC IMMUNE RESPONSES
MONOCYTES AND MACROPHAGES
DENDRITIC CELLS (DCS)
NEUTROPHILS
NK CELLS
NATURAL KILLER T (NKT) CELLS
T CELLS
EMERGING FRONTIERS
REFERENCES
참고문헌 (100)
참고문헌 신청
[학술지(정기간행물)] - Charlton, M. R / 2011 / Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States / Gastroenterology 141 : 1249 ~ 1253
[학술지(정기간행물)] - Lambert, J. E / 2014 / Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease / Gastroenterology 146 : 726 ~ 735
[학술지(정기간행물)] - Romeo, S / 2008 / Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease / Nat. Genet 40 : 1461 ~ 1465
[학술지(정기간행물)] - Kozlitina, J / 2014 / Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease / Nat. Genet 46 : 352 ~ 356
[학술지(정기간행물)] - Adams, L. A / 2005 / The natural history of nonalcoholic fatty liver disease: a population-based cohort study / Gastroenterology 129 : 113 ~ 121
[학술지(정기간행물)] - Lambert, J. E / 2014 / Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease / Gastroenterology 146 : 726 ~ 735
[학술지(정기간행물)] - Romeo, S / 2008 / Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease / Nat. Genet 40 : 1461 ~ 1465
[학술지(정기간행물)] - Kozlitina, J / 2014 / Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease / Nat. Genet 46 : 352 ~ 356
[학술지(정기간행물)] - Adams, L. A / 2005 / The natural history of nonalcoholic fatty liver disease: a population-based cohort study / Gastroenterology 129 : 113 ~ 121
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Pharmacological advances in the treatment of nonalcoholic fatty liver diseases : focused on global results of randomized controlled trials
Clinical and Molecular Hepatology
2023 .02
-
비알코올성 지방간 질환의 진단적 평가
대한내과학회지
2020 .10
-
Recent research trends and updates on nonalcoholic fatty liver disease
Clinical and Molecular Hepatology
2019 .01
-
Noninvasive serum biomarkers for liver steatosis in nonalcoholic fatty liver disease: Current and future developments
Clinical and Molecular Hepatology
2023 .02
-
Pharmacologic therapy for nonalcoholic steatohepatitis focusing on pathophysiology
Journal of Yeungnam Medical Science
2019 .01
-
Pharmacologic therapy for nonalcoholic steatohepatitis focusing on pathophysiology
영남의대학술지
2019 .01
-
Lean vs. obese phenotypes of nonalcoholic fatty liver disease: similar or different?
Clinical and Molecular Hepatology
2023 .04
-
Nonalcoholic fatty liver disease and alcohol-related liver disease: From clinical aspects to pathophysiological insights
Clinical and Molecular Hepatology
2020 .01
-
Surveillance of the progression and assessment of treatment endpoints for nonalcoholic steatohepatitis
Clinical and Molecular Hepatology
2023 .02
-
Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease
Clinical and Molecular Hepatology
2020 .01
-
Recent advances in nonalcoholic fatty liver disease metabolomics
Clinical and Molecular Hepatology
2021 .10
-
Personalized medicine in nonalcoholic fatty liver disease
Clinical and Molecular Hepatology
2022 .10
-
Liver transplantation for non-alcoholic fatty liver disease: indications and post-transplant management
Clinical and Molecular Hepatology
2023 .02
-
A crystal ball to forecast treatment responsiveness in nonalcoholic fatty liver disease
Clinical and Molecular Hepatology
2022 .07
-
Serum lipocalin-2 is a potential biomarker for the clinical diagnosis of nonalcoholic steatohepatitis
Clinical and Molecular Hepatology
2021 .01
-
Screening and prediction of nonalcoholic fatty liver disease using a peripheral insulin resistance index: Potential benefits and limitations
Clinical and Molecular Hepatology
2022 .10
-
Screening strategies for non-alcoholic fatty liver disease: a holistic approach is needed
Clinical and Molecular Hepatology
2023 .04
-
Atorvastatin on Treatment of Nonalcoholic Fatty Liver Disease Patients
전남의대학술지
2024 .01
-
Rho-Kinase as a Therapeutic Target for Nonalcoholic Fatty Liver Diseases
Diabetes and Metabolism Journal
2021 .09
-
State-of-the-Art Overview of the Pharmacological Treatment of Non-Alcoholic Steatohepatitis
Endocrinology and Metabolism
2022 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2017-517-000870467