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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 223 - 228 (6page)
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6-Gingerol exerts anti-tumor effects in various cancer cell models. We evaluated the effect of 6-gingerol on the growth of MCF-7 breast cancer cells and MCF-10A breast epithelial cells to determine whether any growth-inhibitory effects found were attributable to apoptosis, and to elucidate the underlying mechanism of action. 6-Gingerol inhibited the viability of both cell lines in a dose- and time-dependent manner; however, the degree of inhibition was greater in MCF-7 than MCF-10A cells. By flow cytometry, induction of dose- and time-dependent apoptosis was found, and the magnitude of apoptosis was also markedly greater in MCF-7 than MCF-10A cells. Expression of caspase-3 and poly (ADP-ribose) polymerase (PARP) was observed in MCF-7 cells treated with 6-gingerol, and further cleavage of PARP occurred in these cells. We suggest that 6-gingerol induces apoptosis in human breast cancer cells mainly by promoting caspase-3 expression and subsequent degradation of PARP.
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참고문헌 (22)
참고문헌 신청
David W. Koh / 2005 / Mediation of cell death by poly(ADP-ribose) polymerase-1 / Pharmacological Research 52 (1) : 5 ~ 14
Deepali K. Hattangadi / 2004 / Influence of p53 and caspase 3 activity on cell death and senescence in response to methotrexate in the breast tumor cell / Biochemical Pharma
Eunyong Lee / 1998 / Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol / Cancer Letters 134 (2) : 163 ~ 168
Freddie Bray / 2004 / The changing global patterns of female breast cancer incidence and mortality / Breast Cancer Research 6 (6) : 229 ~
Grant KL / 2000 / Gingerol / Am J Health Syst Pharm 57 : 945 ~ 947
Deepali K. Hattangadi / 2004 / Influence of p53 and caspase 3 activity on cell death and senescence in response to methotrexate in the breast tumor cell / Biochemical Pharma
Eunyong Lee / 1998 / Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol / Cancer Letters 134 (2) : 163 ~ 168
Freddie Bray / 2004 / The changing global patterns of female breast cancer incidence and mortality / Breast Cancer Research 6 (6) : 229 ~
Grant KL / 2000 / Gingerol / Am J Health Syst Pharm 57 : 945 ~ 947
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