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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 444 - 453 (10page)
- DOI
- 10.14348/molcells.2018.2311
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초록· 키워드
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Aberrations in histone modifications are being studied in mixed-lineage leukemia (MLL)-AF9-driven acute myeloid leukemia (AML). In this study, we focused on the reg-ulation of the differentiation of the MLL-AF9 type AML cell line THP-1. We observed that, upon phorbol 12-myristate 13-acetate (PMA) treatment, THP-1 cells differentiated into monocytes by down-regulating Aurora kinase A (AURKA), resulting in a reduction in H3S10 phosphorylation. We revealed that the AURKA inhibitor alisertib accelerates the expression of the H3K27 demethylase KDM6B, thereby dissociating AURKA and YY1 from the KDM6B promoter region. Using Flow cytometry, we found that alisertib induces THP-1 differentiation into monocytes. Furthermore, we found that treatment with the KDM6B inhibitor GSK-J4 perturbed the PMA-mediated differentiation of THP-1 cells. Thus, we discovered the mechanism of AURKA?KDM6B signaling that controls the differentiation of THP-1 cells, which has implications for biotherapy for leukemia.
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등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Agger, K. / 2007 / UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development / Nature 449:731~734
Asada, M. / 1999 / Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation / EMBO J. 18:1223~1234
Auwerx, J. / 1991 / The human leukemia cell line, THP-1: a multifacetted model for the study of monocyte-macrophage differentiation / Experientia 47:22~31
Cantu, C. / 2011 / Sox6 enhances erythroid differentiation in human erythroid progenitors / Blood 117:3669~3679
Chang, E. / 2016 / The combination of FLT3 and DNA methyltransferase inhibition is synergistically cytotoxic to FLT3/ITD acute myeloid leukemia cells / Leukemia 30:1025~1032
Asada, M. / 1999 / Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation / EMBO J. 18:1223~1234
Auwerx, J. / 1991 / The human leukemia cell line, THP-1: a multifacetted model for the study of monocyte-macrophage differentiation / Experientia 47:22~31
Cantu, C. / 2011 / Sox6 enhances erythroid differentiation in human erythroid progenitors / Blood 117:3669~3679
Chang, E. / 2016 / The combination of FLT3 and DNA methyltransferase inhibition is synergistically cytotoxic to FLT3/ITD acute myeloid leukemia cells / Leukemia 30:1025~1032
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