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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.9
- 수록면
- 821 - 828 (8page)
- DOI
- 10.14348/molcells.2015.0174
이용수
초록· 키워드
오류제보하기
Monocytes are the major inflammatory cells that infiltrate most solid tumors in humans. The interaction of tumor cells with infiltrating monocytes and their adhesion to these monocytes play a significant role in altering the tumor to become more aggressive. Recently, exposure to lipopolysaccharide (LPS) was suggested to promote cancer cell adhesion to monocytes; however, little is known about the details of the signaling mechanism involved in this process. In this study, we found that LPS up-regulates ICAM-1 expression in MDA-MB-231 breast cancer cells, which facilitates their adhesion to THP-1 monocytes. In addition, we analyzed the signaling mechanism underlying the up-regulation of ICAM-1 and found that the siRNAmediated depletion of BLT2 markedly suppressed the LPSinduced expression of ICAM-1 in MDA-MB-231 cells and the subsequent adhesion of these cells to THP-1 monocytes.
Moreover, we demonstrated that myeloid differentiation primary response gene 88 (MyD88) lies downstream of LPS/TLR4 and upstream of BLT2 and that this ‘MyD88- BLT2’ cascade mediates ERK activation and subsequent ICAM-1 expression, which is critical for the adhesion of MDA-MB-231 cells to THP-1 monocytes. Taken together, our results demonstrate for the first time that LPS upregulates ICAM-1 expression in breast cancer cells via a MyD88-BLT2-ERK-linked signaling cascade, leading to the increased adhesion of breast cancer cells to monocytes.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Blot, E. / 2003 / Cooperation between monocytes and breast cancer cells promotes factors involved in cancer aggressiveness / Br J. Cancer 88:1207~1212
Cargnello, M. / 2011 / Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases / Microbiol. Mol. Biol. Rev 75:50~83
Chaves, M. M. / 2014 / Leukotriene B4 modulates P2X7receptor-mediated Leishmania amazonensis elimination in murine macrophages / J. Immunol 192:4765~4773
Chen, C. / 2014 / Lipopolysaccharide induces the interactions of breast cancer and endothelial cells via activated monocytes / Cancer Lett 345:75~84
Chittezhath, M. / 2014 / Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression / Immunity 41:815~829
Cargnello, M. / 2011 / Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases / Microbiol. Mol. Biol. Rev 75:50~83
Chaves, M. M. / 2014 / Leukotriene B4 modulates P2X7receptor-mediated Leishmania amazonensis elimination in murine macrophages / J. Immunol 192:4765~4773
Chen, C. / 2014 / Lipopolysaccharide induces the interactions of breast cancer and endothelial cells via activated monocytes / Cancer Lett 345:75~84
Chittezhath, M. / 2014 / Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression / Immunity 41:815~829
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