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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제1호
- 발행연도
- 2019.1
- 수록면
- 151 - 159 (9page)
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초록· 키워드
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Lipoteichoic acid isolated from Lactobacillus plantarum K8 (pLTA) alleviates lipopolysaccharide (LPS)-induced excessive inflammation through inhibition of TNF-α and interleukin (IL)-6. In addition, pLTA increases the survival rate of mice in a septic shock model. In the current study, we have found that pLTA contributes to homeostasis through regulation of pro- and anti-inflammatory cytokine production. In detail, pLTA decreased the production of IL-10 by phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells stimulated with prostaglandin E2 (PGE-2) and LPS. However, TNF-α production which was inhibited by PGE-2+LPS increased by pLTA treatment. The regulatory effects of IL-10 and TNF-α induced by PGE-2 and LPS in PMA-differentiated THP-1 cells were mediated by pLTA, but not by other LTAs isolated from either Staphylococcus aureus (aLTA) or L. sakei (sLTA). Further studies revealed that pLTA-mediated IL-10 inhibition and TNF-α induction in PGE-2+LPS-stimulated PMAdifferentiated THP-1 cells were mediated by dephosphorylation of p38 and phosphorylation of c-Jun N-terminal kinase (JNK), respectively. Reduction of pLTA-mediated IL-10 inhibited the metastasis of breast cancer cells (MDA-MB-231), which was induced by IL-10 or conditioned media prepared from PGE-2+LPS-stimulated PMA-differentiated THP-1 cells. Taken together, our data suggest that pLTA contributes to inflammatory homeostasis through induction of repressed pro-inflammatory cytokines as well as inhibition of excessive antiinflammatory cytokines.
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참고문헌 (23)
참고문헌 신청
Percy MG / 2014 / Lipoteichoic acid synthesis and function in Gram-positive bacteria / Annu. Rev. Microbiol 68:81~100
Kim HG / 2008 / Lipoteichoic acid isolated from Lactobacillus plantarum inhibits lipopolysaccharide-induced TNF-alpha production in THP-1 cells and endotoxin shock in mice / J. Immunol 180:2553~2561
김한근 / 2008 / Inhibitory Effects of Lactobacillus plantarum Lipoteichoic Acid (LTA) onStaphylococcus aureus LTA-Induced Tumor Necrosis Factor-Alpha Production / Journal of Microbiology and Biotechnology 18(6):1191~1196
Hong YF / 2015 / Lipoteichoic acid isolated from Lactobacillus plantarum downregulates UV-induced MMP-1 expression and up-regulates type I procollagen through the inhibition of reactive oxygen species generation / Mol. Immunol 67:248~255
김혜림 / 2015 / Lipoteichoic Acid Isolated from Lactobacillus plantarum Inhibits Melanogenesis in B16F10 Mouse Melanoma Cells / Molecules and Cells 38(2):163~170
Kim HG / 2008 / Lipoteichoic acid isolated from Lactobacillus plantarum inhibits lipopolysaccharide-induced TNF-alpha production in THP-1 cells and endotoxin shock in mice / J. Immunol 180:2553~2561
김한근 / 2008 / Inhibitory Effects of Lactobacillus plantarum Lipoteichoic Acid (LTA) onStaphylococcus aureus LTA-Induced Tumor Necrosis Factor-Alpha Production / Journal of Microbiology and Biotechnology 18(6):1191~1196
Hong YF / 2015 / Lipoteichoic acid isolated from Lactobacillus plantarum downregulates UV-induced MMP-1 expression and up-regulates type I procollagen through the inhibition of reactive oxygen species generation / Mol. Immunol 67:248~255
김혜림 / 2015 / Lipoteichoic Acid Isolated from Lactobacillus plantarum Inhibits Melanogenesis in B16F10 Mouse Melanoma Cells / Molecules and Cells 38(2):163~170
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