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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제1호
- 발행연도
- 2020.1
- 수록면
- 85 - 92 (8page)
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One of the omega-3 essential fatty acids, docosahexaenoic acid (DHA), is a significant constituent of the cell membrane and the precursor of several potent lipid mediators. These mediators are considered to be important in preventing or treating several diseases. Resolvin D5, an oxidized lipid mediator derived from DHA, has been known to exert anti-inflammatory effects. However, the detailed mechanism underlying these effects has not yet been elucidated in human monocytic THP-1 cells. In the present study, we investigated the effects of resolvin D5 on inflammation-related signaling pathways, including the extracellular signal-regulated kinase (ERK)-nuclear factor (NF)-κB signaling pathway. Resolvin D5 downregulated the production of interleukin (IL)-6 and chemokine (C-C motif) ligand 5 (CCL5). Additionally, these inhibitory effects were found to be modulated by mitogen-activated protein kinase (MAPK) and NF-κB in lipopolysaccharide (LPS)-treated THP-1 cells. Resolvin D5 inhibited the LPS-stimulated phosphorylation of ERK and translocation of p65 and p50 into the nucleus, resulting in the inhibition of IL-6 and CCL5 production. These results revealed that resolvin D5 exerts anti-inflammatory effects in LPS-treated THP-1 cells by regulating the phosphorylation of ERK and nuclear translocation of NF-κB.
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참고문헌 (40)
참고문헌 신청
Duvall MG / 2016 / DHA-and EPA-derived resolvins, protectins, and maresins in airway inflammation / Eur. J. Pharmacol 785:144~155
Simopoulos AP / 2002 / Omega-3 fatty acids in inflammation and autoimmune diseases / J. Am. Coll. Nutr 21:495~505
Simopoulos AP / 2008 / The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases / Exp. Biol. Med(Maywood) 233:674~688
Gobbetti T / 2017 / Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection / Proc. Natl. Acad. Sci. USA 114:3963~3968
Luo X / 2019 / Resolvin D5Inhibits neuropathic and Inflammatory pain in male but not female mice : Distinct actions of D-series resolvins in chemotherapy-Induced peripheral neuropathy / Front. Pharmacol 10:745
Simopoulos AP / 2002 / Omega-3 fatty acids in inflammation and autoimmune diseases / J. Am. Coll. Nutr 21:495~505
Simopoulos AP / 2008 / The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases / Exp. Biol. Med(Maywood) 233:674~688
Gobbetti T / 2017 / Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection / Proc. Natl. Acad. Sci. USA 114:3963~3968
Luo X / 2019 / Resolvin D5Inhibits neuropathic and Inflammatory pain in male but not female mice : Distinct actions of D-series resolvins in chemotherapy-Induced peripheral neuropathy / Front. Pharmacol 10:745
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