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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 22 - 28 (7page)
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The histone demethylase lysine-specific demethylase 4A (KDM4A/Jmjd2A) has diverse functions, including involvement in gene regulation and cell cycle, and plays an oncogenic role in cancer cells. The modulation of KDM4A through post-translational modifications remains unclear. Here, we show that small ubiquitin-like modifier (SUMO) 1-mediated modification of KDM4A was required for interaction with tumor suppressor p53. Our data revealed that KDM4A is mainly sumoylated at lysine residue 471. However, the SUMO modification resulted in little change in subcellular localization, demethylase activity, or protein stability of KMD4A. Intriguingly, co-immunoprecipitation data revealed that sumoylation-defective mutants of KDM4A had a lower binding ability with p53 compared to that of wild-type KDM4A, suggesting a positive role for sumoylation in the interaction between KDM4A and p53. Together, these data suggest that KDM4A is post-translationally modified by SUMO, and this sumoylation may be a novel regulatory switch for controlling the interplay between KDM4A and p53.
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참고문헌 (25)
참고문헌 신청
Anand R / 2007 / Structure and mechanism of lysine-specific demethylase enzymes / J Biol Chem 282:35425~35429
Baba A / 2011 / PKA-Dependent Regulation of the histone lysine demethylase complex PHF2-ARID5B / Nat Cell Biol 13:668~675
Bueno MTD / 2013 / SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase / Epigenetics 8:1162~1175
Cheng M-b / 2014 / Specific phosphorylation of histone demethylase KDM3A determines target gene expression in response to heat shock / PLoS Biol 12
Cloos PAC / 2008 / Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease / Genes Dev 22:1115~1140
Baba A / 2011 / PKA-Dependent Regulation of the histone lysine demethylase complex PHF2-ARID5B / Nat Cell Biol 13:668~675
Bueno MTD / 2013 / SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase / Epigenetics 8:1162~1175
Cheng M-b / 2014 / Specific phosphorylation of histone demethylase KDM3A determines target gene expression in response to heat shock / PLoS Biol 12
Cloos PAC / 2008 / Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease / Genes Dev 22:1115~1140
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