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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 827 - 835 (9page)
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Background Anti-Müllerian hormone (Amh) plays a critical role in both early sex determination and later gonad development in vertebrate species. However, it remains unknown in northern snakehead (Channa argus), which is economically important freshwater fish with sexual dimorphism. Objective This study aimed to identify the expression profiles and estrogenic regulation of CaAmh during gonadal sex differentiation in C. argus. Methods The cDNA and genomic DNA sequences of CaAmh were identified by PCR and RACE techniques. The expression patterns of CaAmh were detected by qRT-PCR during the gonadal sex differentiation and after 17α-ethinyloestradiol (EE2) treatments. Results CaAmh is composed of seven exons and six introns, and its full-length cDNA is 2413 bp in length, with 1635 bp open reading frame (ORF) that encodes a 544 amino acid protein. Tissues expression patterns revealed that CaAmh display the highest expression in testis of XY males (40.36 folds, p < 0.01). The spatio-temporal expression patterns during gonadal sex differentiation indicated that CaAmh expression differed between XX females and XY males at 30 day after hatching (dah), and reached to the peak (36.03 folds, p < 0.01) at 90 dah in XY gonads. However, CaAmh expression in XX gonads remained low throughout the sampling period. Furthermore, CaAmh expression in the gonads (ovaries) of the sex-reversed XY fish (XY-F) by the administration of estrogen EE2 was downregulated to low level, similar to that in ovaries of normal XX females (XX-F). Conclusions These results show that Amh plays a critical role in testicular differentiation of C. argus and it is apparently modulated by estrogens in this species.
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참고문헌 (33)
참고문헌 신청
Anttonen M / 2005 / High GATA-4expression associates with aggressive behavior, whereas low anti-Müllerian hormone expression associates with growth potential of ovarian granulosa cell tumors / J Clin Endocrinol Metab 90:6529~6535
Behringer RR / 1994 / Müllerian-inhibiting substance function during mammalian sexual development / Cell 79:415~425
Bej DK / 2017 / A duplicated, truncated amh gene is involved in male sex determination in an old world silverside / G3 Genes Genomes Genet 7:2489~2495
Blasco M / 2010 / Molecular characterization of cyp11a1 and cyp11b1 and their gene expression profile in pejerrey(Odontesthes bonariensis)during early gonadal development / Comp Biochem Physiol A Mol Integr Physiol 156:110~118
Fernandino JI / 2008 / Expression profile and estrogenic regulation of anti-müllerian hormone during gonadal development in pejerrey Odontesthes bonariensis, a teleost fish with strong temperature-dependent sex determination / Dev Dyn 237:3192~3199
Behringer RR / 1994 / Müllerian-inhibiting substance function during mammalian sexual development / Cell 79:415~425
Bej DK / 2017 / A duplicated, truncated amh gene is involved in male sex determination in an old world silverside / G3 Genes Genomes Genet 7:2489~2495
Blasco M / 2010 / Molecular characterization of cyp11a1 and cyp11b1 and their gene expression profile in pejerrey(Odontesthes bonariensis)during early gonadal development / Comp Biochem Physiol A Mol Integr Physiol 156:110~118
Fernandino JI / 2008 / Expression profile and estrogenic regulation of anti-müllerian hormone during gonadal development in pejerrey Odontesthes bonariensis, a teleost fish with strong temperature-dependent sex determination / Dev Dyn 237:3192~3199
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