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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,253 - 1,259 (7page)
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Despite a low risk of liver failure and preserved liver function, non-cirrhotic hepatocellular carcinoma (HCC) has a poor prognosis. In the current study, we evaluated an active regulator of SIRT1 (AROS) as a prognostic biomarker in non-cirrhotic HCC. mRNA levels of AROS were measured in tumor and non-tumor tissues obtained from 283 non-cirrhotic HCC patients. AROS expression was exclusively up-regulated in recurrent tissues from the non-cirrhotic HCC patients (P = 0.015) and also in tumor tissues irrespective of tumor stage (P < 0.001) or BCLC stage (P < 0.001). High mRNA levels of AROS were statistically significantly associated with tumor stage (P < 0.001), BCLC stage (P = 0.007), alpha fetoprotein (AFP) level (P = 0.013), microvascular invasion (P = 0.001), tumor size (P = 0.036), and portal vein invasion (P = 0.005). Kaplan-Meir curve analysis demonstrated that HCC patients with higher AROS levels had shorter disease-free survival (DFS) in both the short-term (P < 0.001) and long-term (P = 0.005) compared to those with low AROS. Cox regression analysis demonstrated that AROS is a significant predictor for DFS along with large tumor size, tumor multiplicity, vascular invasion, and poor tumor differentiation, which are the known prognostic factors. In conclusion, AROS is a significant biomarker for tumor aggressiveness in non-cirrhotic hepatocellular carcinoma.
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참고문헌 (29)
참고문헌 신청
Yang JD / 2010 / Hepatocellular carcinoma : A global view / Nat Rev Gastroenterol Hepatol 7:448~458
Kew MC / 1984 / Relationship between hepatocellular carcinoma and cirrhosis / Semin Liver Dis 4:136~146
Trevisani F / 1995 / Etiologic factors and clinical presentation of hepatocellular carcinoma. Differences between cirrhotic and noncirrhotic Italian patients / Cancer 75:2220~2232
Nzeako UC / 1996 / Hepatocellular carcinoma in cirrhotic and noncirrhotic livers. A clinico-histopathologic study of 804 North American patients / Am J Clin Pathol 105:65~75
Bosch FX / 1999 / Epidemiology of primary liver cancer / Semin Liver Dis 19:271~285
Kew MC / 1984 / Relationship between hepatocellular carcinoma and cirrhosis / Semin Liver Dis 4:136~146
Trevisani F / 1995 / Etiologic factors and clinical presentation of hepatocellular carcinoma. Differences between cirrhotic and noncirrhotic Italian patients / Cancer 75:2220~2232
Nzeako UC / 1996 / Hepatocellular carcinoma in cirrhotic and noncirrhotic livers. A clinico-histopathologic study of 804 North American patients / Am J Clin Pathol 105:65~75
Bosch FX / 1999 / Epidemiology of primary liver cancer / Semin Liver Dis 19:271~285
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