지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 366 - 373 (8page)
이용수
초록· 키워드
오류제보하기
Purpose Advanced hepatocellular carcinoma (HCC) is associated with various clinical conditions including major vessel invasion, metastasis, and poor performance status. The aim of this study was to establish a prognostic scoring system and to propose a sub-classification of the Barcelona-Clinic Liver Cancer (BCLC) stage C. Materials and Methods This retrospective study included consecutive patients who received sorafenib for BCLC stage C HCC at a single tertiary hospital in Korea. A Cox proportional hazard model was used to develop a scoring system, and internal validation was performed by a 5-fold cross-validation. The performance of the model in predicting risk was assessed by the area under the curve and the Hosmer-Lemeshow test. Results A total of 612 BCLC stage C HCC patients were sub- classified into strata depending on their performance status. Five independent prognostic factors (Child-Pugh score, -fetoprotein, tumor type, extrahepatic metastasis, and portal vein invasion) were identified and used in the prognostic scoring system. This scoring system showed good discrimination (area under the receiver operating characteristic curve, 0.734 to 0.818) and calibration functions (both p < 0.05 by the Hosmer-Lemeshow test at 1 month and 12 months, respectively). The differences in survival among the different risk groups classified by the total score were significant (p < 0.001 by the log-rank test in both the Eastern Cooperative Oncology Group 0 and 1 strata). Conclusion The heterogeneity of patients with BCLC stage C HCC requires sub-classification of advanced HCC. A prognostic scoring system with five independent factors is useful in predicting the survival of patients with BCLC stage C HCC.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Park JW / 2015 / Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study / Liver Int 35:2155~2166
El-Serag HB / 2011 / Hepatocellular carcinoma / N Engl J Med 365:1118~1127
Sherman M / 2010 / Hepatocellular carcinoma: epidemiology, surveillance, and diagnosis / Semin Liver Dis 30:3~16
Chan AC / 2008 / Changing paradigm in the management of hepatocellular carcinoma improves the survival benefit of early detection by screening / Ann Surg 247:666~673
Llovet JM / 2003 / Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival / Hepatology 37:429~442
El-Serag HB / 2011 / Hepatocellular carcinoma / N Engl J Med 365:1118~1127
Sherman M / 2010 / Hepatocellular carcinoma: epidemiology, surveillance, and diagnosis / Semin Liver Dis 30:3~16
Chan AC / 2008 / Changing paradigm in the management of hepatocellular carcinoma improves the survival benefit of early detection by screening / Ann Surg 247:666~673
Llovet JM / 2003 / Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival / Hepatology 37:429~442
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Hepatic Resection Provides Survival Benefit for Selected Intermediate-Stage (BCLC-B) Hepatocellular Carcinoma Patients
Cancer Research and Treatment
2019 .01
-
Barcelona Clinic Liver Cancer 중간 병기 간세포암종 환자의 병기세분화
Journal of Liver Cancer
2016 .01
-
Treatment Outcomes and Prognostic Factors of Acute Variceal Bleeding in Patients with Hepatocellular Carcinoma
Gut and Liver
2020 .01
-
A Proposal for Modification of the Barcelona Clinic Liver Cancer Staging System Considering the Prognostic Implication of Performance Status
Gut and Liver
2019 .01
-
Evaluation of the Outcome after Transarterial Chemoembolization; Refinement of Barcelona Clinic Liver Cancer Stage-B from Eastern Point of View
Journal of Liver Cancer
2016 .01
-
Advances in Management of Hepatocellular Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Subclassification of advanced-stage hepatocellular carcinoma with macrovascular invasion: combined transarterial chemoembolization and radiotherapy as an alternative first-line treatment
Journal of Liver Cancer
2023 .03
-
Clinical practice guidelines and real-life practice in hepatocellular carcinoma: A Taiwan perspective
Clinical and Molecular Hepatology
2023 .04
-
Conventional and machine learning-based risk scores for patients with early-stage hepatocellular carcinoma
Clinical and Molecular Hepatology
2024 .07
-
Intermediate-stage hepatocellular carcinoma: refining substaging or shifting paradigm?
Journal of Liver Cancer
2024 .03
-
A Novel Model for Predicting Hepatocellular Carcinoma Development in Patients with Chronic Hepatitis B and Normal Alanine Aminotransferase Levels
Gut and Liver
2017 .07
-
Risk score model for the development of hepatocellular carcinoma in treatment-naive patients receiving oral antiviral treatment for chronic hepatitis B
Clinical and Molecular Hepatology
2017 .06
-
Serum fibrosis index-based risk score predicts hepatocellular carcinoma in untreated patients with chronic hepatitis B
Clinical and Molecular Hepatology
2021 .01
-
Survival benefit of liver resection in BCLC-B stage hepatocellular carcinoma : A Korean nationwide multicenter study with propensity score matching
한국간담췌외과학회 학술대회지
2016 .04
-
Hepatocellular Carcinoma in Korea Between 2008 and 2011: an Analysis of Korean Nationwide Cancer Registry
Journal of Liver Cancer
2020 .01
-
Detect or not to detect very early stage hepatocellular carcinoma? The western perspective
Clinical and Molecular Hepatology
2019 .01
-
Appraisal of a Model to Estimate Survival in Ambulatory Patients with Hepatocellular Carcinoma Classified as Barcelona Clinic Liver Cancer Stage B
Gut and Liver
2020 .01
-
Construction and validation of a preoperative prognostic model integrating the novel aspartate aminotransferase-albumin score for hepatocellular carcinoma patients undergoing liver resection
Annals of Hepato-Biliary-Pancreatic Surgery
2024 .11
-
Establishment of a Disease-Specific Graded Prognostic Assessment for Hepatocellular Carcinoma Patients with Spinal Metastasis
Gut and Liver
2017 .07
-
Survival-Related Factors of Spinal Metastasis with Hepatocellular Carcinoma in Current Surgical Treatment Modalities : A Single Institute Experience
대한신경외과학회지
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0