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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.94 No.3
- 발행연도
- 2018.3
- 수록면
- 129 - 134 (6page)
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Purpose: Although few hepatectomy patients develop unexpected early diffuse and multinodular recurrence in the remnant liver, the prognosis in such cases is often dismal. The aim of this study was to evaluate the risk factors of early disseminated multinodular hepatocellular carcinoma (HCC) recurrence within 3 months after liver resection for solitary HCC.
Methods: Eighty-four patients who were diagnosed with recurrent HCC within 3 months after hepatectomy for solitary HCC were retrospectively reviewed. Disseminated HCC recurrence was defined as more than 10 tumors in both lobes and total tumor size >10 cm.
Results: Preoperative α-FP level, incidence of poor tumor grade, and presence of portal vein tumor thrombosis were higher in the patients with disseminated HCC recurrence than in those without disseminated HCC recurrence (P < 0.05). Multivariate analysis showed that α-FP >1,000 ng/dL was a predisposing factor of disseminated HCC recurrence within 3 months after liver resection. The overall survival rate for patients without disseminated HCC recurrence was higher than that for patients with disseminated HCC recurrence (P < 0.001).
Conclusion: Early disseminated multinodular HCC recurrence in hepatectomy patients was associated with preoperative α-FP >1,000 ng/dL. Such patients should be frequently evaluated for the early detection of recurrent HCC for early intervention.
Methods: Eighty-four patients who were diagnosed with recurrent HCC within 3 months after hepatectomy for solitary HCC were retrospectively reviewed. Disseminated HCC recurrence was defined as more than 10 tumors in both lobes and total tumor size >10 cm.
Results: Preoperative α-FP level, incidence of poor tumor grade, and presence of portal vein tumor thrombosis were higher in the patients with disseminated HCC recurrence than in those without disseminated HCC recurrence (P < 0.05). Multivariate analysis showed that α-FP >1,000 ng/dL was a predisposing factor of disseminated HCC recurrence within 3 months after liver resection. The overall survival rate for patients without disseminated HCC recurrence was higher than that for patients with disseminated HCC recurrence (P < 0.001).
Conclusion: Early disseminated multinodular HCC recurrence in hepatectomy patients was associated with preoperative α-FP >1,000 ng/dL. Such patients should be frequently evaluated for the early detection of recurrent HCC for early intervention.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (17)
참고문헌 신청
[학술지(정기간행물)] - Cherqui D / 2009 / Liver resection for transplantable hepatocellular carcinoma: long-term survival and role of secondary liver transplantation / Ann Surg 250 : 738 ~ 746
[학술지(정기간행물)] - Lee HY / 2013 / Early diffuse recurrence of hepatocellular carcinoma after percutaneous radiofrequency ablation: analysis of risk factors / Eur Radiol 23 : 190 ~ 197
[학술지(정기간행물)] - Kim JM / 2014 / Outcomes after curative hepatectomy in patients with non-B non-C hepatocellular carcinoma and hepatitis B virus hepatocellular carcinoma from non-cirrhotic liver / J Surg Oncol 110 : 976 ~ 981
[학술지(정기간행물)] - Kim JM / 2014 / Differences between hepatocellular carcinoma and hepatitis B virus infection in patients with and without cirrhosis / Ann Surg Oncol 21 : 458 ~ 465
[학술지(정기간행물)] - Imamura H / 2003 / Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy / J Hepatol 38 : 200 ~ 207
[학술지(정기간행물)] - Lee HY / 2013 / Early diffuse recurrence of hepatocellular carcinoma after percutaneous radiofrequency ablation: analysis of risk factors / Eur Radiol 23 : 190 ~ 197
[학술지(정기간행물)] - Kim JM / 2014 / Outcomes after curative hepatectomy in patients with non-B non-C hepatocellular carcinoma and hepatitis B virus hepatocellular carcinoma from non-cirrhotic liver / J Surg Oncol 110 : 976 ~ 981
[학술지(정기간행물)] - Kim JM / 2014 / Differences between hepatocellular carcinoma and hepatitis B virus infection in patients with and without cirrhosis / Ann Surg Oncol 21 : 458 ~ 465
[학술지(정기간행물)] - Imamura H / 2003 / Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy / J Hepatol 38 : 200 ~ 207
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UCI(KEPA) : I410-ECN-0101-2018-514-001804873