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논문 기본 정보

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학술저널
저자정보
Jongbeom Shin (Department of Internal Medicine Inha University Hospital Inha University School of Medicine) Jung Hwan Yu (Department of Internal Medicine Inha University Hospital Inha University School of Medicine) Young-Joo Jin (Department of Internal Medicine Inha University Hospital Inha University School of Medicine) Jin-Woo Lee (Department of Internal Medicine Inha University Hospital Inha University School of Medicine)
저널정보
대한간암학회 Journal of Liver Cancer Journal of Liver Cancer Vol.21 No.1
발행연도
2021.1
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34 - 44 (11page)

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Background/objective: Hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) is rarely observed in patients without liver cirrhosis (LC). We evaluated the incidence and clinical feature of HCV-associated HCC patients with or without LC. Methods: The medical records of 1,516 patients diagnosed as having primary HCC at our hospital between January 2005 and December 2017 were retrospectively reviewed. Of these, 154 (10.2%) HCV-associated HCC patients were analyzed. LC was diagnosed histologically or clinically. Results: Seventeen (11.0%) of the 154 patients had non-cirrhotic HCC, and all were of Child-Turcotte-Pugh (CTP) class A, Among the 17 patients, 88.2% were male, all had nodular type HCC, and only 2 (11.8%) were under HCC surveillance. Median overall survival (OS) of HCVassociated HCC patients with and without LC was 15 months and 37 months, respectively. Cumulative OS rates were not different between non-cirrhotic patients and cirrhotic patients with CTP class A (P=0.229). Cumulative OS rates were significantly higher in non-cirrhotic patients than in cirrhotic patients of CTP class B (P<0.001) or C (P<0.001). Multivariate analyses showed serum AST (hazard ratio [HR] 1.01, P=0.003) and AFP levels (HR 1.01, P=0.016), antiviral therapy (HR 0.25, P=0.022), and LC of CTP class B (HR, 5.24, P=0.006) or C (HR 21.79, P<0.001) were significantly associated with prognosis in HCV-associated HCC patients. Conclusions: HCC in a non-cirrhotic liver was found in 11% of HCV-associated HCC patients. OSs of HCV-associated HCC patients were better in those of CTP A, regardless of LC than in those with LC of CTP class B or C.
#Hepatocellular carcinoma #Hepatitis C virus #Cirrhosis #Non-cirrhosis

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참고문헌 (39)

참고문헌 신청
Global Burden of Disease Cancer C / 2017 / Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study / JAMA Oncol 3:524~548 google schola El-Serag HB / 2012 / Epidemiology of viral hepatitis and hepatocellular carcinoma / Gastroenterology 142:1264~1273 google schola Trevisani F / 2010 / Hepatocellular carcinoma in non-cirrhotic liver : a reappraisal / Dig Liver Dis 42:341~347 google schola Evert M / 2008 / Hepatocellular carcinoma in the noncirrhotic liver / Pathologe 29:47~52 google schola Do AL / 2014 / Hepatocellular carcinoma incidence in noncirrhotic patients with chronic hepatitis B and patients with cirrhosis of all etiologies / J Clin Gastroenterol 48:644~649 google schola

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