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Roles of Tumor Markers in Diagnosis and Treatment of Hepatocellular Carcinoma
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간세포암의 진단과 치료에서 종양표지자의 역할

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Type
Academic journal
Author
장영 (순천향대학교 부속 서울병원 소화기내과) 장재영 (순천향대학교 부속 서울병원 소화기내과)
Journal
The Korean Association Of Internal Medicine 대한내과학회지 대한내과학회지 제95권 제1호 KCI Candidated Journals
Published
2020.2
Pages
31 - 35 (5page)
DOI
https://doi.org/10.3904/kjm.2020.95.1.31

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Roles of Tumor Markers in Diagnosis and Treatment of Hepatocellular Carcinoma
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Abstract· Keywords

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There are a wide variety of tumor markers for hepatocellular carcinoma (HCC). Studies are ongoing regarding the roles of tumor markers in screening, diagnosis, treatment, and prognostic prediction of HCC. Serum alpha-fetoprotein (AFP) can be very useful for HCC surveillance, prognostic prediction, and treatment response evaluation in high-risk patients with HCC. Other tumor markers such as PIVKA-II and AFP-L3% have also been proven to be effective in HCC diagnosis, follow-up, and prognostic prediction; these markers are increasingly used with serum AFP in clinical trials. However, the roles of tumor markers in surveillance are poorly understood and still controversial, requiring further research. HCC surveillance in at-risk population is a critical issue in management of HCC. Further data regarding the predictive value and cost-effectiveness of tumor markers could facilitate their uses in HCC surveillance.
#Carcinoma hepatocellular #Biomakers #tumor #Alpha-Fetoprotein #PIVKA-II #AFP-L3%

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References (42)

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Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68:394~424 google schola Kanwal F / 2019 / Surveillance for hepatocellular carcinoma : current best practice and future direction / Gastroenterology 157:54~64 google schola van Meer S / 2015 / Surveillance for hepatocellular carcinoma is associated with increased survival : results from a large cohort in the Netherlands / J Hepatol 63:1156~1163 google schola Mittal S / 2016 / Effectiveness of surveillance for hepatocellular carcinoma in clinical practice : a United States cohort / J Hepatol 65:1148~1154 google schola Omata M / 2017 / Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma : a 2017 update / Hepatol Int 11:317~370 google schola

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