지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제51권 제1호
- 발행연도
- 2017.1
- 수록면
- 79 - 86 (8page)
이용수
초록· 키워드
오류제보하기
Background: Liver transplantation (LT) is the treatment of choice for hepatocellular carcinoma (HCC). The aim of this study was to investigate the recurrence rate of HCC after LT and prognostic factors for recurrence by comparing LT with non-transplanted resection. Methods: The participants were 338 patients who underwent LT between 1996 and 2012 at Seoul National University Hospital (LT group) and 520 HCC patients who underwent partial hepatectomy between 1995 and 2006 (control group, non-LT group). Results: In the LT group, 68 of 338 patients (19.8%) showed relapse, and the recurrence rate was lower than that in the non-LT group (64.9%, 357/520, p < .001). Stratification analysis by American Joint Committee on Cancer (AJCC) stage showed that the stage I-II LT group had a lower recurrence rate than the non-LT group. Univariate comparative analysis demonstrated that multiplicity of tumor, tumor size, gross type, Edmondson-Steiner (ES) nuclear grade, extent of tumor, angioinvasion, AJCC stage, Milan criteria, University of California at San Francisco criteria on explant pathology (all p < .001), positive expression of cytokeratin 19 (p = .002), and preoperative α-fetoprotein (AFP) (p < .001) were predictors of tumor recurrence. In multivariate analysis, LT, preoperative AFP, multiplicity of tumor, extent of tumor, size of tumor, and ES nuclear grade were independent prognostic factors. Conclusions: LT might have a protective effect against the late recurrence of stage I-II HCC compared to non-LT, and the prognostic factors for recurrence were similar to previously well-known prognostic factors for HCC.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
/ 1989 / The general rules for the clinical and pathological study of primary liver cancer / Jpn J Surg 19 : 98 ~ 129
Attard G / 2011 / Utilizing circulating tumor cells: challenges and pitfalls / Curr Opin Genet Dev 21 : 50 ~ 58
Donat M / 2016 / Impact of histological factors of hepatocellular carcinoma on the outcome of liver transplantation / Transplant Proc 48 : 1968 ~
Edge SB / 2010 / The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM / Ann Surg Oncol 17 : 1471 ~ 1474
Gondolesi GE / 2004 / Adult living donor liver transplantation for patients with hepatocellular carcinoma: extending UNOS priority criteria / Ann Surg 239 : 142 ~ 149
Attard G / 2011 / Utilizing circulating tumor cells: challenges and pitfalls / Curr Opin Genet Dev 21 : 50 ~ 58
Donat M / 2016 / Impact of histological factors of hepatocellular carcinoma on the outcome of liver transplantation / Transplant Proc 48 : 1968 ~
Edge SB / 2010 / The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM / Ann Surg Oncol 17 : 1471 ~ 1474
Gondolesi GE / 2004 / Adult living donor liver transplantation for patients with hepatocellular carcinoma: extending UNOS priority criteria / Ann Surg 239 : 142 ~ 149
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Validation for models for tumor recurrence after liver transplantation in hepatectomy patients
Annals of Surgical Treatment and Research
2022 .03
-
A comparison of the risk factors of intrahepatic recurrence, early recurrencen, and multiple recurrences after resection for single nodular hepatocellular carcinoma
Annals of Hepato-Biliary-Pancreatic Surgery
2015 .08
-
Change in the Recurrence Pattern and Predictors over Time after Complete Cure of Hepatocellular Carcinoma
Gut and Liver
2021 .01
-
Postresection prognosis of combined hepatocellular carcinoma-cholangiocarcinoma according to the 2010 World Health Organization classification: single-center experience of 168 patients
Annals of Surgical Treatment and Research
2021 .05
-
Protrusion of hepatocellular carcinoma is a predictor of early recurrence in hepatectomy patients after spontaneous rupture
Annals of Surgical Treatment and Research
2016 .06
-
Differences in Prognostic Factors between Early and Late Recurrence Breast Cancers
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Prediction models of hepatocellular carcinoma recurrence after liver transplantation: A comprehensive review
Clinical and Molecular Hepatology
2022 .10
-
Substantial risk of recurrence even after 5 recurrence-free years in early-stage hepatocellular carcinoma patients
Clinical and Molecular Hepatology
2020 .01
-
Risk factors for poor survival after recurrence of hepatocellular carcinoma after liver transplantation
Annals of Surgical Treatment and Research
2021 .07
-
Early disseminated recurrence after liver resection in solitary hepatocellular carcinoma
Annals of Surgical Treatment and Research
2018 .03
-
Prognostic impact of serum soluble PD-1 and ADV score for living donor liver transplantation in patients with previously untreated hepatocellular carcinoma
Annals of Surgical Treatment and Research
2022 .01
-
Blood Neutrophil-to-Lymphocyte Ratio Predicts Tumor Recurrence in Patients with Hepatocellular Carcinoma within Milan Criteria after Hepatectomy
Yonsei Medical Journal
2016 .01
-
Recurrence in patients with totally necrotic nodules of hepatocellular carcinoma after liver transplantation: “totally” an inaccurate description
Annals of Surgical Treatment and Research
2023 .07
-
간세포암의 진단과 치료에서 종양표지자의 역할
대한내과학회지
2020 .02
-
Outcomes of Living Donor Liver Transplantation in Patients with a History of Ruptured Hepatocellular Carcinoma
대한외과학회 학술대회 초록집
2021 .05
-
Long-term outcomes of liver resection for multiple hepatocellular carcinomas: Single-institution experience with 187 patients
Annals of Hepato-Biliary-Pancreatic Surgery
2020 .11
-
Post-resection prognosis of patients with hepatic epithelioid hemangioendothelioma
Annals of Surgical Treatment and Research
2021 .03
-
Prognostic factors after curative resection hepatocellular carcinoma and the surgeon’s role
Annals of Surgical Treatment and Research
2017 .11
-
Risk factors of recurrence in TNM stage I colorectal cancer
Annals of Surgical Treatment and Research
2023 .05
-
Clinical significance and predictive factors of early massive recurrence after radiofrequency ablation in patients with a single small hepatocellular carcinoma
Clinical and Molecular Hepatology
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0