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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,062 - 1,067 (6page)
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The records of 63 high-risk neuroblastoma patients with bone marrow (BM) tumors at diagnosis were retrospectively reviewed. All patients received nine cycles of induction chemotherapy followed by tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT). Follow-up BM examination was performed every three cycles during induction chemotherapy and every three months for one year after the second HDCT/auto-SCT. BM tumor cells persisted in 48.4%, 37.7%, 23.3%, and 20.4% of patients after three, six, and nine cycles of induction chemotherapy and three months after the second HDCT/auto-SCT, respectively. There was no difference in progression-free survival (PFS) rate between patients with persistent BM tumor and those without during the induction treatment. However, after tandem HDCT/auto-SCT, the PFS rate was worse in patients with persistent BM tumor than in those without (probability of 5-yr PFS 14.7% ± 13.4% vs. 64.2% ± 8.3%, P = 0.009). Persistent BM tumor during induction treatment is not associated with a worse prognosis when intensive tandem HDCT/auto-SCT is given as consolidation treatment. However, persistent BM tumor after tandem HDCT/ auto-SCT is associated with a worse prognosis. Therefore, further treatment might be needed in patients with persistent BM tumor after tandem HDCT/auto-SCT.
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참고문헌 (13)
참고문헌 신청
Seeger RC / 2000 / Quantitative tumor cell content of bone marrow and blood as a predictor of outcome in stage IV neuroblastoma : a Children’s Cancer Group Study / J Clin Oncol 18:4067~4076
Fukuda M / 2001 / Disease outcome may be predicted by molecular detection of minimal residual disease in bone marrow in advanced neuroblastoma : a pilot study / J Pediatr Hematol Oncol 23:10~13
Cai JY / 2012 / Minimal residual disease is a prognostic marker for neuroblastoma with bone marrow infiltration / Am J Clin Oncol 35:275~278
Sung KW / 2007 / Tandem high-dose chemotherapy and autologous stem cell rescue / Bone Marrow Transplant 40:37~45
Brodeur GM / 1993 / Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment / J Clin Oncol 11:1466~1477
Fukuda M / 2001 / Disease outcome may be predicted by molecular detection of minimal residual disease in bone marrow in advanced neuroblastoma : a pilot study / J Pediatr Hematol Oncol 23:10~13
Cai JY / 2012 / Minimal residual disease is a prognostic marker for neuroblastoma with bone marrow infiltration / Am J Clin Oncol 35:275~278
Sung KW / 2007 / Tandem high-dose chemotherapy and autologous stem cell rescue / Bone Marrow Transplant 40:37~45
Brodeur GM / 1993 / Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment / J Clin Oncol 11:1466~1477
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