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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,055 - 1,062 (8page)
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초록· 키워드
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Despite increasing evidence that high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT) might improve the survival of patients with high-risk or recurrent solid tumors, therapy effectiveness for bone and soft tissue sarcoma treatment remains unclear. This study retrospectively investigated the feasibility and effectiveness of HDCT/auto-SCT for high-risk or recurrent bone and soft tissue sarcoma. A total of 28 patients (18 high-risk and 10 recurrent) underwent single or tandem HDCT/auto-SCT between October 2004 and September 2014. During follow-up of a median 15.3 months, 18 patients exhibited disease progression and 2 died of treatment-related toxicities (1 veno-occlusive disease and 1 sepsis). Overall, 8 patients remained alive and progressionfree. The 3-year overall survival (OS) and event-free survival (EFS) rates for all 28 patients were 28.7% and 26.3%, respectively. In the subgroup analysis, OS and EFS rates were higher in patients with complete or partial remission prior to HDCT/auto-SCT than in those with worse responses (OS, 39.1% vs. 0.0%, P = 0.002; EFS, 36.8% vs. 0.0%, P < 0.001). Therefore, careful selection of patients who can benefit from HDCT/auto-SCT and maximal effort to reduce tumor burden prior to treatment will be important to achieve favorable outcomes in patients with high-risk or recurrent bone and soft tissue sarcomas.
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참고문헌 (27)
참고문헌 신청
HaDuong JH / 2015 / Sarcomas / Pediatr Clin North Am 62:179~200
Grier HE / 2003 / Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone / N Engl J Med 348:694~701
Meyers PA / 2004 / High-dose therapy with autologous stem cell rescue for pediatric sarcomas / Curr Opin Oncol 16:120~125
Miser JS / 2004 / Treatment of metastatic Ewing’s sarcoma or primitive neuroectodermal tumor of bone : evaluation of combination ifosfamide and etoposide--a Children’s Cancer Group and Pediatric Oncology Group study / J Clin Oncol 22:2873~2876
Weigel BJ / 2016 / Intensive multiagent therapy, including dose-compressed cycles of ifosfamide/etoposide and vincristine/doxorubicin/cyclophosphamide, irinotecan, and radiation, in patients with high-risk rhabdomyosarcoma: a report from the Children’s Oncology Group / J Clin Oncol 34:117~122
Grier HE / 2003 / Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone / N Engl J Med 348:694~701
Meyers PA / 2004 / High-dose therapy with autologous stem cell rescue for pediatric sarcomas / Curr Opin Oncol 16:120~125
Miser JS / 2004 / Treatment of metastatic Ewing’s sarcoma or primitive neuroectodermal tumor of bone : evaluation of combination ifosfamide and etoposide--a Children’s Cancer Group and Pediatric Oncology Group study / J Clin Oncol 22:2873~2876
Weigel BJ / 2016 / Intensive multiagent therapy, including dose-compressed cycles of ifosfamide/etoposide and vincristine/doxorubicin/cyclophosphamide, irinotecan, and radiation, in patients with high-risk rhabdomyosarcoma: a report from the Children’s Oncology Group / J Clin Oncol 34:117~122
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