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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제48권 제4호
발행연도
2016.1
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1,408 - 1,419 (12page)

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Purpose We prospectively evaluated the effectiveness of tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT) in improving the survival of patients with atypical teratoid/rhabdoid tumors while reducing the risks of late adverse effects from radiotherapy (RT). Materials and Methods For young children (< 3 years old), tandem HDCT/auto-SCT was administered after six cycles of induction chemotherapy. RT was deferred until after 3 years of age unless the tumor showed relapse or progression. For older patients (> 3 years old), RT including reduceddose craniospinal RT (23.4 or 30.6 Gy) was administered either after two cycles of induction chemotherapy or after surgery, and tandem HDCT/auto-SCT was administered after six cycles of induction chemotherapy. Results A total of 13 patients (five young and eight older) were enrolled from November 2004 to June 2012. Eight patients, including all five young patients, had metastatic disease at diagnosis. Six patients (four young and two older) experienced progression before initiation of RT, and seven were able to proceed to HDCT/auto-SCT without progression during induction treatment. Three of six patients who experienced progression during induction treatment underwent HDCT/auto-SCT as salvage treatment. All five young patients died from disease progression. However, four of the eight older patients remain progression-free with a median follow-up period of 64 months (range, 39 to 108 months). Treatment-related late toxicities were acceptable. Conclusion The required dose of craniospinal RT might be reduced in older patients if the intensity of chemotherapy is increased. However, early administration of RT should be considered to prevent early progression in young patients.
#Brain neoplasms #Chemotherapy #Hematopoietic stem cell transplantation #Radiotherapy

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참고문헌 (25)

참고문헌 신청
Hilden JM / 2004 / Central nervous system atypical teratoid/rhabdoid tumor : results of therapy in children enrolled in a registry / J Clin Oncol 22:2877~2884 google schola Tekautz TM / 2005 / Atypical teratoid/rhabdoid tumors(ATRT) : improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy / J Clin Oncol 23:1491~1499 google schola Bikowska B / 2011 / Atypical teratoid/rhabdoid tumor : short clinical description and insight into possible mechanism of the disease / Eur J Neurol 18:813~818 google schola von Hoff K / 2011 / Frequency, riskfactors and survival of children with atypical teratoid rhabdoid tumors(AT/RT)of the CNS diagnosed between 1988and 2004, and registered to the German HIT database / Pediatr Blood Cancer 57:978~985 google schola Athale UH / 2009 / Childhood atypical teratoid rhabdoid tumor of the central nervous system : a meta-analysis of observational studies / J Pediatr Hematol Oncol 31:651~663 google schola

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