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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 14 (14page)
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Background: Infants and very young children with malignant brain tumors have a poorer survival and a higher risk for neurologic deficits. The present study evaluated the feasibility and effectiveness of multimodal treatment including tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT) in minimizing use of radiotherapy (RT) in very young children with non-metastatic malignant brain tumors. Methods: Twenty consecutive patients younger than 3 years were enrolled between 2004 and 2017. Tandem HDCT/auto-SCT was performed after six cycles of induction chemotherapy. Local RT was administered only to patients with post-operative gross residual tumor at older than 3 years. Since September 2015, early post-operative local RT for patients with atypical teratoid/rhabdoid tumor or primitive neuroectodermal tumor was administered. Results: All 20 enrolled patients underwent the first HDCT/auto-SCT, and 18 proceeded to the second. Two patients died from toxicity during the second HDCT/auto-SCT, and four patients experienced relapse/progression (one localized and three metastatic), three of whom remained alive after salvage treatment including RT. A total of 17 patients remained alive at a median 7.8 (range, 2.5−15.7) years from diagnosis. Nine survivors received no RT, six survivors received local RT alone, and two survivors who experienced metastatic relapse after tandem HDCT/auto-SCT received both local and craniospinal RT. The 5-year overall, event- free, and craniospinal RT-free survival rates were 85.0% ± 8.0%, 70.0% ± 10.2%, and 75.0% ± 9.7%, respectively. Neuroendocrine and neurocognitive functions evaluated 5 years after tandem HDCT/auto-SCT were acceptable. Conclusion: Our results suggest that non-metastatic malignant brain tumors in very young children could be treated with multimodal therapy including tandem HDCT/auto-SCT while minimizing RT, particularly craniospinal RT.
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참고문헌 (38)
참고문헌 신청
Sung KW / 2013 / Tandem high-dose chemotherapy and autoSCT for malignant brain tumors in children under 3 years of age / Bone Marrow Transplant 48(7):932~938
Duffner PK / 1993 / Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors / N Engl J Med 328(24):1725~1731
Geyer JR / 1994 / Survival of infants with primitive neuroectodermal tumors or malignant ependymomas of the CNS treated with eight drugs in 1 day : a report from the Childrens Cancer Group / J Clin Oncol 12(8):1607~1615
Grill J / 2005 / Treatment of medulloblastoma with postoperative chemotherapy alone : an SFOP prospective trial in young children / Lancet Oncol 6(8):573~580
Berthold F / 2005 / Myeloablative megatherapy with autologous stem-cell rescue versus oral maintenance chemotherapy as consolidation treatment in patients with high-risk neuroblastoma : a randomised controlled trial / Lancet Oncol 6(9):649~658
Duffner PK / 1993 / Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors / N Engl J Med 328(24):1725~1731
Geyer JR / 1994 / Survival of infants with primitive neuroectodermal tumors or malignant ependymomas of the CNS treated with eight drugs in 1 day : a report from the Childrens Cancer Group / J Clin Oncol 12(8):1607~1615
Grill J / 2005 / Treatment of medulloblastoma with postoperative chemotherapy alone : an SFOP prospective trial in young children / Lancet Oncol 6(8):573~580
Berthold F / 2005 / Myeloablative megatherapy with autologous stem-cell rescue versus oral maintenance chemotherapy as consolidation treatment in patients with high-risk neuroblastoma : a randomised controlled trial / Lancet Oncol 6(9):649~658
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