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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 182 - 190 (9page)
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Treatment options for partial thickness cartilage defects are limited. The purpose of this study was to evaluate the efficacy of the chondrocyte-seeded cartilage extracellular matrix membrane in repairing partial thickness cartilage defects. First, the potential of the membrane as an effective cell carrier was investigated. Secondly, we have applied the chondrocyte-seeded membrane in an ex vivo, partial thickness defect model to analyze its repair potential. After culture of chondrocytes on the membrane in vitro, cell viability assay, cell seeding yield calculation and cell transfer assay were done. Cell carrying ability of the membrane was also tested by seeding different densities of cells. Partial defects were created on human cartilage tissue explants. Cell-seeded membranes were applied using a modified autologous chondrocyte implantation technique on the defects and implanted subcutaneously in nude mice for 2 and 4 weeks. In vitro data showed cell viability and seeding yield comparable to standard culture dishes. Time dependent cell transfer from the membrane was observed. Membranes supported various densities of cells. Ex vivo data showed hyaline-like cartilage tissue repair, integrated on the defect by 4 weeks. Overall, chondrocyte-seeded cartilage extracellular membranes may be an effective and feasible treatment strategy for the repair of partial thickness cartilage defects.
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참고문헌 (26)
참고문헌 신청
Hunziker EB / 1996 / Repair of partial-thickness defects in articular cartilage: cell recruitment from the synovial membrane / J Bone Joint Surg Am 78:721~733
Ding C / 2006 / Natural history of knee cartilage defects and factors affecting change / Arch Intern Med 166:651~658
Buckwalter JA / 1998 / Articular cartilage: injuries and potential for healing / J Orthop Sports Phys Ther 28:192~202
Lewandowska K / 1987 / Fibronectin-mediated adhesion of fibroblasts: inhibition by dermatan sulfate proteoglycan and evidence for a cryptic glycosaminoglycan-binding domain / J Cell Biol 105:1443~1454
허성우 / 2014 / The Effect of Platelet Rich Plasma Combined with Microfracture for the Treatment of Chondral Defect in a Rabbit Knee / 조직공학과 재생의학 11(2):178~185
Ding C / 2006 / Natural history of knee cartilage defects and factors affecting change / Arch Intern Med 166:651~658
Buckwalter JA / 1998 / Articular cartilage: injuries and potential for healing / J Orthop Sports Phys Ther 28:192~202
Lewandowska K / 1987 / Fibronectin-mediated adhesion of fibroblasts: inhibition by dermatan sulfate proteoglycan and evidence for a cryptic glycosaminoglycan-binding domain / J Cell Biol 105:1443~1454
허성우 / 2014 / The Effect of Platelet Rich Plasma Combined with Microfracture for the Treatment of Chondral Defect in a Rabbit Knee / 조직공학과 재생의학 11(2):178~185
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