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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 387 - 399 (13page)
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BACKGROUND: Articular cartilage injury has a poor repair ability and limited regeneration capacity with therapy based on articular chondrocytes (ACs) implantation. Here, we validated the hypothesis that human nasal septum-derived chondrocytes (hNCs) are potent therapeutic agents for clinical use in cartilage tissue engineering using an injectable hydrogel, type I collagen (COL1). METHODS: We manufactured hNCs incorporated in clinical-grade soluble COL1 and investigated their clinical potential as agents in an articular defect model. RESULTS: The hNCs encapsulated in COL1 (hNC-collagen) were uniformly distributed throughout the collagen and showed much greater growth rate than hACs encapsulated in collagen for the 14 days of culture. Fluorescent staining of hNC-collagen showed high expression levels of chondrocyte-specific proteins under clinical conditions. Moreover, a negative mycoplasma screening result were obtained in culture of hNC-collagen. Notably, implantation of hNC-collagen increased the repair of osteochondral defects in rats compared with implantation of collagen only. Many human cells were detected within the cartilage defects. CONCLUSION: These results provide reliable evidences supporting for clinical applications of hNC-collagen in regenerative medicine for cartilage repair.
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참고문헌 (44)
참고문헌 신청
Mobasheri A / 2009 / Mesenchymal stem cells in connective tissue engineering and regenerative medicine : applications in cartilage repair and osteoarthritis therapy / Histol Histopathol 24:347~366
Nam BM / 2014 / Effect of cryopreservation and cell passage number on cell preparations destined for autologous chondrocyte transplantation / Transplant Proc. 46:1145~1149
Kon E / 2013 / Matrix assisted autologous chondrocyte transplantation for cartilage treatment : a systematic review / Bone Joint Res 2:18~25
Kim DH / 2018 / Characteristics of nasal septal cartilage-derived progenitor cells during prolonged cultivation / Otolaryngol Head Neck Surg 159:774~782
Pelttari K / 2017 / Nasal chondrocytes as a neural crest-derived cell source for regenerative medicine / Curr Opin Biotechnol 47:1~6
Nam BM / 2014 / Effect of cryopreservation and cell passage number on cell preparations destined for autologous chondrocyte transplantation / Transplant Proc. 46:1145~1149
Kon E / 2013 / Matrix assisted autologous chondrocyte transplantation for cartilage treatment : a systematic review / Bone Joint Res 2:18~25
Kim DH / 2018 / Characteristics of nasal septal cartilage-derived progenitor cells during prolonged cultivation / Otolaryngol Head Neck Surg 159:774~782
Pelttari K / 2017 / Nasal chondrocytes as a neural crest-derived cell source for regenerative medicine / Curr Opin Biotechnol 47:1~6
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Engineering technique for dedifferentiation inhibition of nasal septum chondrocytes by compressed circumstance
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Preparation of an injectable hydrogel derived from porcine articular cartilage as a biomedical material
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Intra-Articular Atelocollagen Injection for the Treatment of Articular Cartilage Defects in Rabbit Model
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