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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 13 (13page)
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BACKGROUND: Advances in cartilage tissue engineering have demonstrated noteworthy potential for developing cartilage for implantation onto sites impacted by joint degeneration and injury. To supplement resource-intensive in vivo and in vitro studies required for cartilage tissue engineering, computational models and simulations can assist in enhancing experimental design. METHODS: Research articles pertinent to cartilage tissue engineering and computer modeling were identified, reviewed, and summarized. Various applications of computer modeling for cartilage tissue engineering are highlighted, limitations of in silico modeling are addressed, and suggestions for future work are enumerated. RESULTS: Computational modeling can help better characterize shear stresses generated by bioreactor fluid flow, refine scaffold geometry, customize the mechanical properties of engineered cartilage tissue, and model rates of cell growth and dynamics. Thus, results from in silico studies can help resourcefully enhance in vitro and in vivo studies; however, the limitations of these studies, such as the underlying assumptions and simplifications applied in each model, should always be addressed and justified where applicable. In silico models should also seek validation and verification when possible. CONCLUSION: Future studies may adopt similar approaches to supplement in vitro trials and further investigate effects of mechanical stimulation on chondrocyte and stem cell dynamics. Additionally, as precision medicine, machine learning, and powerful open-source software become more popular and accessible, applications of multi-scale and multiphysics computational models in cartilage tissue engineering are expected to increase.
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참고문헌 (72)
참고문헌 신청
Litwic A / 2013 / Epidemiology and burden of osteoarthritis / Br Med Bull 105:185~199
Plotnikoff R / 2015 / Osteoarthritis prevalence and modifiable factors: a population study / BMC Public Health 15:1195
Nelson AE / 2014 / A systematic review of recommendations and guidelines for the management of osteoarthritis: the chronic osteoarthritis management initiative of the U.S. bone and joint initiative / Semin Arthritis Rheum 43:701~712
Xu M / 2016 / Chondrocytes derived from mesenchymal stromal cells and induced pluripotent cells of patients with familial osteochondritis dissecans exhibit an endoplasmic reticulum stress response and defective matrix assembly / Stem Cells Transl Med 5:1171~1181
Vahdati A / 2012 / Computational investigation of fibrin mechanical and damage properties at the interface between native cartilage and implant / J Biomech Eng 134:111004
Plotnikoff R / 2015 / Osteoarthritis prevalence and modifiable factors: a population study / BMC Public Health 15:1195
Nelson AE / 2014 / A systematic review of recommendations and guidelines for the management of osteoarthritis: the chronic osteoarthritis management initiative of the U.S. bone and joint initiative / Semin Arthritis Rheum 43:701~712
Xu M / 2016 / Chondrocytes derived from mesenchymal stromal cells and induced pluripotent cells of patients with familial osteochondritis dissecans exhibit an endoplasmic reticulum stress response and defective matrix assembly / Stem Cells Transl Med 5:1171~1181
Vahdati A / 2012 / Computational investigation of fibrin mechanical and damage properties at the interface between native cartilage and implant / J Biomech Eng 134:111004
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