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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 287 - 299 (13page)
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Scaffolds with cartilage-like environment and suitable physical properties are critical for tissue-engineered cartilage repair. In this study, decellularized porcine cartilage-derived extracellular matrix (ECM) was utilized to fabricate ECM scaffolds. Mechanically reinforced ECM scaffolds were developed by combining salt-leaching and crosslinking for cartilage repair. The developed scaffolds were investigated with respect to their physicochemical properties and their cartilage tissue formation ability. The mechanically reinforced ECM scaffold showed similar mechanical strength to that of synthetic PLGA scaffold and expressed higher levels of cartilage-specific markers compared to those expressed by the ECM scaffold prepared by simple freeze-drying. These results demonstrated that the physical properties of ECM-derived scaffolds could be influenced by fabrication method, which provides suitable environments for the growth of chondrocytes. By extension, this study suggests a promising approach of natural biomaterials in cartilage tissue engineering.
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참고문헌 (46)
참고문헌 신청
Patra D / 2012 / Antiangiogenic and anticancer molecules in cartilage / Expert Rev Mol Med 14:e10
허성우 / 2016 / Autologous Bone Marrow Mesenchymal Cell Induced Chondrogenesis for the Treatment of Osteoarthritis of Knee / 조직공학과 재생의학 13(2):200~209
Chung C / 2008 / Engineering cartilage tissue / Adv Drug Deliv Rev 60:243~262
이지민 / 2017 / Effects of Trichostatin A on the Chondrogenesis from Human Mesenchymal Stem Cells / 조직공학과 재생의학 14(4):403~410
Chinmaya Mahapatra / 2016 / Alginate-Hyaluronic Acid-Collagen Composite Hydrogel Favorable for the Culture of Chondrocytes and Their Phenotype Maintenance / 조직공학과 재생의학 13(5):538~546
허성우 / 2016 / Autologous Bone Marrow Mesenchymal Cell Induced Chondrogenesis for the Treatment of Osteoarthritis of Knee / 조직공학과 재생의학 13(2):200~209
Chung C / 2008 / Engineering cartilage tissue / Adv Drug Deliv Rev 60:243~262
이지민 / 2017 / Effects of Trichostatin A on the Chondrogenesis from Human Mesenchymal Stem Cells / 조직공학과 재생의학 14(4):403~410
Chinmaya Mahapatra / 2016 / Alginate-Hyaluronic Acid-Collagen Composite Hydrogel Favorable for the Culture of Chondrocytes and Their Phenotype Maintenance / 조직공학과 재생의학 13(5):538~546
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