지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 178 - 185 (8page)
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Recently, many clinical studies have been published regarding platelet-rich plasma (PRP) injection for early degenerative joint disease. We evaluated the cartilage repair potential of platelet-rich plasma when injected into the knee joint. Articular, cartilage defects 4mm in diameter and circular in shape were made in the trochlear region of 20 knees in 10 New Zealand white rabbits who were divided into two groups. The left knees in the control group underwent microfracture, and the right knees in the experimental group underwent microfracture with subsequent injection of platelet-rich plasma. At week 12 following the surgery, the cartilage was observed macroscopically and histologically compared in the two groups. The control group showed incomplete and irregular fibrous tissue formation in the defect. The experimental group showed nearly complete defect coverage with neo-cartilage. In the histologic scoring, comparison of the control group and the experimental group differed significantly (p<0.05).Therefore, injection of platelet-rich plasma used to treat articular cartilage defects of the knee appears to have some effect forcartilage regeneration.
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참고문헌 (32)
참고문헌 신청
OS Schindler / 2011 / Current concepts of articular cartilage repair / Acta Orthop Belg 77:709
DW Richardson / 1990 / Biochemical changes in articular cartilage opposing full- and partial-thickness cartilage lesions in horses / Am J Vet Res 51:118
E Wagner / 2009 / Non-surgical treatment of osteoarthritis of large joints - new aspects / Wien Med Wochenschr 159:76
EC Rodriguez-Merchan / 2012 / The treatment of cartilage defects in the knee joint: microfracture, mosaicplasty, and autologous chondrocyte implantation / Am J Orthop(Belle Mead NJ) 41:236
T Furukawa / 1980 / Biochemical studies on repair cartilage resurfacing experimental defects in the rabbit knee / J Bone Joint Surg Am 62:79
DW Richardson / 1990 / Biochemical changes in articular cartilage opposing full- and partial-thickness cartilage lesions in horses / Am J Vet Res 51:118
E Wagner / 2009 / Non-surgical treatment of osteoarthritis of large joints - new aspects / Wien Med Wochenschr 159:76
EC Rodriguez-Merchan / 2012 / The treatment of cartilage defects in the knee joint: microfracture, mosaicplasty, and autologous chondrocyte implantation / Am J Orthop(Belle Mead NJ) 41:236
T Furukawa / 1980 / Biochemical studies on repair cartilage resurfacing experimental defects in the rabbit knee / J Bone Joint Surg Am 62:79
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