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Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctionalprotein that plays a central role in the cellular response to DNA damage and redoxregulation against oxidative stress. APE1/Ref-1 functions in the DNA base excision repairpathway, the redox regulation of several transcription factors, and the control ofintracellular redox status through the inhibition of reactive oxygen species (ROS)production. APE1/Ref-1 is predominantly localized in the nucleus; however, its subcellularlocalization is dynamically regulated and it may be found in the mitochondriaor elsewhere in the cytoplasm. Studies have identified a nuclear localization signal anda mitochondrial target sequence in APE1/Ref-1, as well as the involvement of the nuclearexport system, as determinants of APE1/Ref-1 subcellular distribution. Recently,it was shown that APE1/Ref-1 is secreted in response to hyperacetylation at specificlysine residues. Additionally, post-translational modifications such as phosphorylation,S-nitrosation, and ubiquitination appear to play a role in fine-tuning the activitiesand subcellular localization of APE1/Ref-1. In this review, we will introduce themultifunctional role of APE1/Ref-1 and its potential usefulness as a therapeutic targetin cancer and cardiovascular disease.
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참고문헌 (61)
참고문헌 신청
Beckman KB / 1997 / Oxidative decay of DNA / J Biol Chem 272:19633~19636
Georgiadis MM / 2008 / Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease / Mutat Res 643:54~63
Luo M / 2012 / Characterization of the redox activity and disulfide bond formation in apurinic/apyrimidinic endonuclease / Biochemistry 51:695~705
박명수 / 2013 / Cytoplasmic Localization and Redox Cysteine Residue of APE1/Ref-1 Are Associated with Its Anti-Inflammatory Activity in Cultured Endothelial Cells / Molecules and Cells 36(5):439~445
Tell G / 2009 / The many functions of APE1/Ref-1: not only a DNA repair enzyme / Antioxid Redox Signal 11:601~620
Georgiadis MM / 2008 / Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease / Mutat Res 643:54~63
Luo M / 2012 / Characterization of the redox activity and disulfide bond formation in apurinic/apyrimidinic endonuclease / Biochemistry 51:695~705
박명수 / 2013 / Cytoplasmic Localization and Redox Cysteine Residue of APE1/Ref-1 Are Associated with Its Anti-Inflammatory Activity in Cultured Endothelial Cells / Molecules and Cells 36(5):439~445
Tell G / 2009 / The many functions of APE1/Ref-1: not only a DNA repair enzyme / Antioxid Redox Signal 11:601~620
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