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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 242 - 249 (8page)
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이 논문의 연구 히스토리 (3)
2016
H₂O₂ 처리된 LLC-PK₁세포에서 Redox Status 및 NF-κB Signaling에 대한 夏枯草의 효과
손종석
,
정지천
동의생리병리학회지
2016.08
학술저널
H2O2 처리된 LLC-PK₁세포에서 Redox Status 및 NF-κB Signaling에 대한 夏枯草의 효과
손종석
한의학과
2016.01
학위논문
H<sub>2</sub>O<sub>2</sub> 처리된 LLC-PK₁세포에서 Redox Status 및 NF-κB Signaling에 대한 하고초(夏枯草)의 효과
손종석
,
정지천
동의생리병리학회지
2016.01
학술저널
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초록· 키워드
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This study was to investigate the anti-inflammatory effects of Prunellae Herba(PH). The generation of superoxide anion radical (？O<sub>2</sub>-), nitric oxide (NO), peroxynitrite (ONOO-) and Prostaglandin E₂(PGE<sub>2</sub>) were measured in the H<sub>2</sub>O<sub>2</sub>-Treated renal epithelial cells(LLC-PK1 cell) of mouse. And the effects of Prunellae Spica on the expression of NF-κB (p50, p65), IKK-α, phospho-IκB-α and inflammation-related proteins, COX-2, iNOS, IL-1β and VCAM-1, were examined by western blot. The fluorescent probes, 2',7'-dichlorodihydrofluorescein diacetate (DCFDA), 4,5-diaminofluorescein (DAF-2) and dihyldrorhodamine 123 (DHR 123) were used to estimate the scavenging effect of Prunellae Spica on ？O<sub>2</sub>-, NO, ONOO-. Western blot was conducted to assess the protein expression levels of NF-κB (p50, p65), IKK-α, phospho-IκB-α, inflammation-related proteins, COX-2, iNOS, IL-1β, VCAM-1. PH inhibited H<sub>2</sub>O<sub>2</sub>-treated cell death dose-dependently. It reduced the generation of ·O<sub>2</sub>-, NO, ONOO- and PGE₂ in the H<sub>2</sub>O<sub>2</sub>-treated renal epitheial cells(LLC-PK<sub>1</sub> cell) of mouse in vitro. PH reduced the expression of NF-κB, IKK-α, phospho-IκB-α, COX-2, iNOS, IL-1β and VCAM-1 genes through means of decreasing activation of NF-κB signaling as well. According to these results, PH has an antioxidative activity and anti-inflammatory effect by regulating the NF-κB pathway. This suggest that PH is expected to be used to regulating inflammatory process and treating inflammation-related disease.
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