지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 823 - 833 (11page)
이용수
초록· 키워드
오류제보하기
Purpose Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctionalprotein that shows elevated expression in a number of cancers. We attempted to determinewhether serum APE1/Ref-1 is elevated in patients with bladder cancer.
Materials and MethodsSerum APE1/Ref-1 levels were determined using enzyme-linked immunosorbent assay inserum from patients with bladder cancer who had not received chemotherapy or radiotherapy(n=51) and non-tumor controls (n=55). The area under the receiver operating characteristicarea under the curve was applied to determine the correlation between clinicalfactors and the serum levels of APE1/Ref-1.
ResultsSerum levels of APE1/Ref-1 in bladder cancer patients were significantly elevated comparedto those of the control group (3.548±0.333 ng/100 μL [n=51] for bladder cancer vs.
1.547±0.319 ng/100 μL [n=55] for the control group), with a sensitivity and specificity of93% and 59%, respectively. Serum APE1/Ref-1 levels are associated with tumor stage,grade, muscle invasion, and recurrence.
ConclusionSerum APE1/Ref-1 might be useful as a potential serologic biomarker for bladder cancer.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Brimo F / 2009 / Accuracy of urine cytology and the significance of an atypical category / Am J Clin Pathol 132 : 785 ~ 793
Choi S / 2013 / Histone deacetylases inhibitor trichostatin A modulates the extracellular release of APE1/Ref-1 / Biochem Biophys Res Commun 435 : 403 ~ 407
Dai N / 2013 / Serum APE1 autoantibodies: a novel potential tumor marker and predictor of chemotherapeutic efficacy in non-small cell lung cancer / PLoS One 8 : e58001 ~
Fluss R / 2005 / Estimation of the Youden Index and its associated cutoff point / Biom J 47 : 458 ~ 472
German RR / 2011 / The accuracy of cancer mortality statistics based on death certificates in the United States / Cancer Epidemiol 35 : 126 ~ 131
Choi S / 2013 / Histone deacetylases inhibitor trichostatin A modulates the extracellular release of APE1/Ref-1 / Biochem Biophys Res Commun 435 : 403 ~ 407
Dai N / 2013 / Serum APE1 autoantibodies: a novel potential tumor marker and predictor of chemotherapeutic efficacy in non-small cell lung cancer / PLoS One 8 : e58001 ~
Fluss R / 2005 / Estimation of the Youden Index and its associated cutoff point / Biom J 47 : 458 ~ 472
German RR / 2011 / The accuracy of cancer mortality statistics based on death certificates in the United States / Cancer Epidemiol 35 : 126 ~ 131
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Altered Secretory Activity of APE1/Ref-1 D148E Variants Identified in Human Patients With Bladder Cancer
International Neurourology Journal
2016 .01
-
Dynamic Regulation of APE1/Ref-1 as a Therapeutic Target Protein
전남의대학술지
2016 .01
-
Role of APE1/Ref-1 in hydrogen peroxide-induced apoptosis in human renal HK-2 cells
Kidney Research and Clinical Practice
2024 .03
-
Apurinic/apyrimidinic endonuclease 1 is associated with poor prognosis after curative resection followed by adjuvant chemotherapy in patients with stage III colon cancer
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2022 .06
-
Ref-1 protects against FeCl3-induced thrombosis and tissue factor expression via the GSK3?NF-κB pathway
The Korean Journal of Physiology & Pharmacology
2021 .01
-
Temporal Trends of the Prevalence of Abdominal Obesity and Metabolic Syndrome in Korean Children and Adolescents between 2007 and 2020
Journal of Obesity & Metabolic Syndrome
2023 .06
-
Genetic and Epigenetic Alterations in Bladder Cancer
International Neurourology Journal
2016 .01
-
Revascularization and limb restoration in critical limb ischemia by nanoceria-induced Ref-1/APE1-dependent angiogenesis
대한치과재료학회 학술대회
2021 .04
-
Biomarkers for bladder cancer: The search continues!
Investigative and Clinical Urology
2016 .01
-
Improving the diagnosis of high grade and stage bladder cancer by detecting increased urinary calprotectin expression in tumor tissue and tumor-associated inflammatory response
Investigative and Clinical Urology
2019 .01
-
OK-432 Suppresses Proliferation and Metastasis by Tumor Associated Macrophages in Bladder Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Changing landscape of diagnosis and treatment of bladder cancer
Investigative and Clinical Urology
2016 .01
-
Toward Better Predictions of Chemosensitivity: Comparative Study of Conventional and Simulated Chemosensitivity Tests for Bladder Cancer Cell Lines
Annals of Laboratory Medicine
2017 .07
-
Evaluation of the antinociceptive activities of natural propolis extract derived from stingless bee Trigona thoracica in mice
The Korean Journal of Pain
2024 .04
-
Incidence of kidney, bladder, and prostate cancers in Korea: An update
Investigative and Clinical Urology
2015 .01
-
Implantable Bladder Sensors: A Methodological Review
International Neurourology Journal
2015 .01
-
Gender-related outcomes in robot-assisted radical cystectomy: A multi-institutional study
Investigative and Clinical Urology
2022 .01
-
Implantable Bladder Sensors for Long-term Monitoring of Bladder Volume
International Neurourology Journal
2015 .01
-
Organoid culture of bladder cancer cells
Investigative and Clinical Urology
2018 .01
-
Diabetes is an Important Risk Factor for Metastasis in Non-Muscle-Invasive Bladder Cancer
Asian Pacific journal of cancer prevention : APJCP
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0