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Acrosorium polyneurum Extract Inhibits the LPS-Induced Inflammatory Response by Impairing the MAPK and NF-κB Pathways
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Type
Academic journal
Author
Zahid Manzoor (Jeju National University) Irshad Ali (Jeju National University) Doobyeong Chae (Jeju National University) Young-Sang Koh (Jeju National University)
Journal
Korean Society Of Virology JOURNAL OF BACTERIOLOGY AND VIROLOGY Vol.46 No.4 KCI Accredited Journals SCOPUS
Published
2016.12
Pages
288 - 294 (7page)

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Acrosorium polyneurum Extract Inhibits the LPS-Induced Inflammatory Response by Impairing the MAPK and NF-κB Pathways
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Marine algae exhibit broad spectrum anti-bacterial and anti-inflammatory activities. Acrosorium polyneurum (A. polyneurum) is a marine red alga and belongs to the family Delesseriaceae. The present research evaluates the anti-inflammatory effects of A. polyneurum extract (APE) on pro-inflammatory cytokine production. APE demonstrated substantial inhibitory effects on production of pro-inflammatory cytokine in bone marrow-derived macrophages (BMDMs). APE pre-treatment in the lipopolysaccharide (LPS)-stimulated BMDMs exhibited a robust inhibitory effect on production of interleukin (IL)-12, IL-6 and tumor necrosis factor (TNF)-α. It revealed a robust inhibitory effect on phosphorylation of ERK1/2, JNK1/2 and p38. APE also showed remarkable inhibitory effect on phosphorylation and degradation of IκBα. Furthermore, APE pre-treatment demonstrated substantial inhibition of LPS-induced production of nitric oxide and inducible nitric oxide synthase. Collectively, these data suggest that APE has a noteworthy anti-inflammatory property and deserve further studies concerning its potential use as a medicinal agent for inflammation-related disorders.
#Acrosorium polyneurum #Mitogen-activated protein kinase #NF-κB #Nitric oxide #Pro-inflammatory cytokine

Contents

INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES

References (27)

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[학술지(정기간행물)] - Takeuchi O / 2010 / Pattern recognition receptors and inflammation / Cell 140 : 805 ~ 820 google schola [학술지(정기간행물)] - Zahid Manzoor / 2012 / Mitogen-activated Protein Kinases in Inflammation / Journal of Bacteriology and Virology 42 (3) : 189 ~ 195 dbpia [학술지(정기간행물)] - 고영상 / 2011 / Nucleic Acid Recognition and Signaling by Toll-like Receptor 9: Compartment-dependent Regulation / Journal of Bacteriology and Virology 41 (2) : 131 ~ 132 google schola [학술지(정기간행물)] - Efron PA / 2005 / Differential maturation of murine bone-marrow derived dendritic cells with lipopolysaccharide and tumor necrosis factor-α / J Endotoxin Res 11 : 145 ~ 160 google schola [학술지(정기간행물)] - Zahid Manzoor / 2014 / Mitogen-activated Protein Kinase Signaling in Inflammation-related Carcinogenesis / Journal of Bacteriology and Virology 44 (4) : 297 ~ 304 dbpia

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