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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제38권 제3호
- 발행연도
- 2016.3
- 수록면
- 1 - 9 (9page)
- DOI
- 10.1186/s40902-016-0061-5
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초록· 키워드
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Background: The association of biomaterial combined with repair factor-like platelet-rich plasma (PRP) has prospectivevalues. Bovine-derived xenograft has been identified as an osteoconductive and biocompatible grafting material thatprovides osseointegration ability. PRP has become a valuable adjunctive agent to promote healing in a lot of dentaland oral surgery procedures. However, there are controversies with respect to the regenerative capacity of PRP and thereal benefits of its use in bone grafts. The purpose of this study was to assess the influence of PRP combined withxenograft for the repair of peri-implant bone defects.
Methods: Twelve rabbits were used in this study, and the experimental surgery with implant installation wasperformed simultaneously. Autologous PRP was prepared before the surgical procedure. An intrabony defect(7.0 mm in diameter and 3.0 mm deep) was created in the tibia of each rabbit; then, 24 titanium dental implants(3.0 mm in diameter and 8.5 mm long) were inserted into these osteotomy sites. Thus, a standardized gap (4.0 mm)was established between the surrounding bony walls and the implant surface. The gaps were treated with eitherxenograft alone (control group) or xenograft combined with PRP (experimental group). After healing for 1, 2, 3, 4, 5,and 6 weeks, the rabbits were sacrificed with an overdose of KCl solution. Two rabbits were killed at each time, and thesamples including dental implants and surrounding bone were collected and processed for histological analysis.
Results: More newly formed bone and a better bone healing process were observed in control group. Thehistomorphometric analysis revealed that the mean percentage of bone-to-implant contact in the control group wassignificantly higher than that of the experimental group (25.23 vs. 8.16 %; P < 0.05, independent-simple t test, analysis ofvariance [ANOVA]).
Conclusions: The results indicate that in the addition of PRP to bovine-derived xenograft in the repair of bone defectsaround the implant, PRP may delay peri-implant bone healing.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Lang N / 1994 / Immediate transmucosal implants using the principle of guided tissue regeneration. I. Rationale, clinical procedures and 30-month results / Clin Oral Implants Res 5:154~163
Landsberg CJ / 1997 / Socket seal surgery combined with immediate implant placement: a novel approach for single tooth replacement / Int J Periodontics Restorative Dent 17:141~149
Becker BE / 1998 / A prospective clinical trial of endosseous screw-shaped implants placed at the time of tooth extraction without augmentation / J Periodontol 69:920~926
Retzepi M / 2010 / Guided bone regeneration: biological principles and theurapeutic applications / Clin Oral Implants Res 21:567~576
Marx RE / 1998 / Platelet-rich plasma: growth factor enhancement for bone grafts / Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85:638~646
Landsberg CJ / 1997 / Socket seal surgery combined with immediate implant placement: a novel approach for single tooth replacement / Int J Periodontics Restorative Dent 17:141~149
Becker BE / 1998 / A prospective clinical trial of endosseous screw-shaped implants placed at the time of tooth extraction without augmentation / J Periodontol 69:920~926
Retzepi M / 2010 / Guided bone regeneration: biological principles and theurapeutic applications / Clin Oral Implants Res 21:567~576
Marx RE / 1998 / Platelet-rich plasma: growth factor enhancement for bone grafts / Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85:638~646
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