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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 463 - 472 (10page)
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이 논문의 연구 히스토리 (3)
2016
Baseline-Corrected QT (QTc) Interval Is Associated with Prolongation of QTc during Severe Hypoglycemia in Patients with Type 2 Diabetes Mellitus
차선아
,
윤재승
,
임태석
외 7명
Diabetes and Metabolism Journal
2016.01
학술저널
Severe Hypoglycemia and Cardiovascular or All-Cause Mortality in Patients with Type 2 Diabetes
차선아
,
윤재승
,
임태석
외 7명
Diabetes and Metabolism Journal
2016.01
학술저널
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초록· 키워드
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Background: We investigated an association between baseline heart rate-corrected QT (QTc) interval before severe hypoglycemia (SH) and prolongation of QTc interval during SH in patients with type 2 diabetes mellitus (T2DM). Methods: Between January 2004 and June 2014, 208 patients with T2DM, who visited the emergency department because of SH and underwent standard 12-lead electrocardiography within the 6-month period before SH were consecutively enrolled. The QTc interval was analyzed during the incidence of SH, and 6 months before and after SH. QTc intervals of 450 ms or longer in men and 460 ms or longer in women were considered abnormally prolonged. Results: The mean age and diabetes duration were 68.1±12.1 and 14.1±10.1 years, respectively. The mean QTc intervals at baseline and SH episodes were 433±33 and 460±33 ms, respectively (P<0.001). One hundred and fourteen patients (54.8%) had a prolonged QTc interval during SH. There was a significant decrease in the prolonged QTc interval within 6 months after SH (QTc interval prolongation during SH vs. after recovery, 54.8% vs. 33.8%, P<0.001). The prolonged QTc interval was significantly associated with baseline QTc interval prolongation (odds ratio, 2.92; 95% confidence interval, 1.22 to 6.96; P=0.016) after adjusting for multiple confounders. Conclusion: A prolonged QTc interval at baseline was significantly associated with prolongation of the QTc interval during SH in patients with T2DM, suggesting the necessity of QTc interval monitoring and attention to those with a prolonged QTc interval to prevent SH.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Selvin E / 2004 / Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus / Ann Intern Med 141:421~431
Stratton IM / 2000 / Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study / BMJ 321:405~412
The DCCT Research Group / 1987 / Diabetes Control and Complications Trial (DCCT): results of feasibility study / Diabetes Care 10:1~19
Ohkubo Y / 1995 / Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study / Diabetes Res Clin Pract 28:103~117
Zoungas S / 2010 / Severe hypoglycemia and risks of vascular events and death / N Engl J Med 363:1410~1418
Stratton IM / 2000 / Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study / BMJ 321:405~412
The DCCT Research Group / 1987 / Diabetes Control and Complications Trial (DCCT): results of feasibility study / Diabetes Care 10:1~19
Ohkubo Y / 1995 / Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study / Diabetes Res Clin Pract 28:103~117
Zoungas S / 2010 / Severe hypoglycemia and risks of vascular events and death / N Engl J Med 363:1410~1418
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