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논문 기본 정보

자료유형
학술저널
저자정보
Han-Joon Bae (Daegu Catholic University College of Medicine) Hyun Jun Cho (Daegu Fatima General Hospital) Chan-Hee Lee (Yeungnam University College of Medicine) Myung Hwan Bae (Kyungpook National University) Hyoung-Seob Park (Keimyung University Dongsan Medical Center) Byung Chun Jung (Daegu Fatima General Hospital) Dong-Gu Shin (Yeungnam University College of Medicine) Yongkeun Cho (Kyungpook National University) Jongmin Hwang (Keimyung University Dongsan Medical Center) Seongwook Han (Keimyung University Dongsan Medical Center) Kyu-Hwan Park (Daegu Veterans Hospital) Se Yong Jang (Kyungpook National University Chilgok Hospital) Young Soo Lee (Daegu Catholic University College of Medicine)
저널정보
대한심장학회 Korean Circulation Journal Korean Circulation Journal Vol.51 No.10
발행연도
2021.10
수록면
851 - 862 (12page)
DOI
https://doi.org/10.4070/kcj.2021.0116

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Background and Objectives: As the coronavirus disease 2019 (COVID-19) spreads worldwide, cardiac injury in patients infected with COVID-19 becomes a significant concern. Thus, this study investigates the impact of several electrocardiogram (ECG) parameters and disease severity in COVID-19 patients. Methods: Seven medical centers in Daegu admitted 822 patients with COVID-19 between February and April 2020. This study examined 267 patients among them who underwent an ECG test and evaluated their biochemical parameters like C-reactive protein (CRP), log N-terminal pro-B-type Natriuretic Peptide (NT-proBNP), cardiac enzyme, and ECG parameters (heart rate, PR interval, QRS interval, T inversion, QT interval, and Tpe [the interval between peak to end in a T wave]). Results: Those patients were divided into 3 groups of mild (100 patients), moderate (89 patients), and severe (78 patients) according to clinical severity score. The level of CRP, log NT-proBNP, and creatinine kinase-myocardial band were significantly increased in severe patients. Meanwhile, severe patients exhibited prolonged QT intervals (QTc) and Tpe (Tpe-c) compared to mild or moderate patients. Moreover, deceased patients (58; 21.7%) showed increased dispersion of QTc and Tpe-c compared with surviving patients (78.2±41.1 vs. 40.8±24.6 ms and 60.2±37.3 vs. 40.8±24.5 ms, both p<0.05, respectively). The QTc dispersion of more than 56.1 ms could predict the mortality in multivariate analysis (odd ratio, 11.55; 95% confidence interval, 3.746?42.306). Conclusions: COVID-19 infections could involve cardiac injuries, especially cardiac repolarization abnormalities. A prolonged QTc dispersion could be an independent predictable factor of mortality.

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