지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 159 - 166 (8page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaSome antidepressants have been implicated as risk factors for QT prolongation, which is a predictor of sudden cardiac death. However, the QT interval is considered an imperfect biomarker for proarrhythmic risk. Therefore, we reevaluated the risk of sudden cardiac death due to antidepressants using improved methods, namely, QT dispersion (QTD), T wave peak-to-end interval (Tp-e), and Tp-e/QT ratio. MethodsaaWe compared the effects of antidepressants on QTc (QT/RR1/3), QTD, Tp-e, and Tp-e/QT ratio in 378 patients with mood disorder. We also compared each index between 165 healthy controls and 215 randomly selected age-matched patients. ResultsaaAge (p<0.01), sex (p<0.05), tricyclic antidepressant (TCA) use (p<0.05), and clomipramine (p<0.01) and mianserin (p<0.05) use in particular, significantly associated with a prolonged QTc. We also found that age (p<0.01), TCA use (p<0.05), and clomipramine (p<0.01) and mianserin (p<0.05) use in particular, significantly prolonged QTD. However, there was no correlation between each variable and Tp-e or Tp-e/QT ratio. Significant differences in QTc and QTD were found between the patients and healthy controls. ConclusionaaFrom our results, prediction of risk of sudden cardiac death by QTD, Tp-e, or Tp-e/QT ratio was inconsistent. Increased QTD may be more suitable for predicting sudden cardiac death due to antidepressants.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Sicouri S / 2008 / Sudden cardiac death secondary to antidepressant and antipsychotic drugs / Expert Opin Drug Saf 7:181~194
Hamer M / 2011 / Antidepressant medication use and future risk of cardiovascular disease : the Scottish Health Survey / Eur Heart J 32:437~442
Whang W / 2009 / Depression and risk of sudden cardiac death and coronary heart disease in women : results from the Nurses' Health Study / J Am Coll Cardiol 53:950~958
Straus SM / 2006 / Prolonged QTc interval and risk of sudden cardiac death in a population of older adults / J Am Coll Cardiol 47:362~367
Reilly JG / 2000 / QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients / Lancet 355:1048~1052
Hamer M / 2011 / Antidepressant medication use and future risk of cardiovascular disease : the Scottish Health Survey / Eur Heart J 32:437~442
Whang W / 2009 / Depression and risk of sudden cardiac death and coronary heart disease in women : results from the Nurses' Health Study / J Am Coll Cardiol 53:950~958
Straus SM / 2006 / Prolonged QTc interval and risk of sudden cardiac death in a population of older adults / J Am Coll Cardiol 47:362~367
Reilly JG / 2000 / QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients / Lancet 355:1048~1052
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