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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Purpose: The aims of the present study were twofold. First, the research investigated the effect of an individual’s risk factors and the prevalence of psychotropic drugs on QTc prolongation, TdP (torsades de pointes), and death. Second, the study compared the risk scoring systems (the Mayo Pro-QT risk score and the Tisadale risk score) on QTc prolongation. Methods: The medical records of intoxicated patients who visited the emergency department between March 2010 and February 2019 were reviewed retrospectively. Among 733 patients, the present study included 426 psychotropic drug-intoxicated patients. The patients were categorized according to the QTc value. The known risk factors of QTc prolongation were examined, and the Mayo Pro-QT risk score and the Tisadale risk score were calculated. The analysis was performed using multiple logistic regression, Spearman correlation, and ROC (receiver operating characteristic). Results: The numbers in the mild to moderate group (male: 470≤QTc<500 ms, female: 480≤QTc<500 ms) and severe group (QTc≥500 ms or increase of QTc at least 60ms from baseline, both sex) were 68 and 95, respectively. TdP did not occur, and the only cause of death was aspiration pneumonia. The statically significant risk factors were multidrug intoxications of TCA (tricyclic antidepressant), atypical antipsychotics, an atypical antidepressant, panic disorder, and hypokalemia. The Tisadale risk score was larger than the Mayo Pro-QT risk score. Conclusion: Multiple psychotropic drugs intoxication (TCA, an atypical antidepressant, and atypical antipsychotics), panic disorder, and hypokalemia have been proven to be the main risk factors of QTc prolongation, which require enhanced attention. The present study showed that the Tisadale score had a stronger correlation and predictive accuracy for QTc prolongation than the Mayo Pro-QT score. As a result, the Tisadale risk score is a crucial assessment tool for psychotropic drug-intoxicated patients in a clinical setting.
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참고문헌 (37)
참고문헌 신청
Organisation for Economic Co-operation and Development
2020- 2018 National Survey on Suicide South Korea Ministry of Health and Welfare
Talia L. Brown / 2018 / Access to Psychotropic Medication via Prescription Is Associated With Choice of Psychotropic Medication as Suicide Method / The Journal of Clinical Psychiatry 79(6)
Pentti M. Rautaharju / 2009 / AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram / Circulation 119(10):241~250
Peter M. Haddad / 2002 / Antipsychotic-Related QTc Prolongation, Torsade de Pointes and Sudden Death / Drugs 62(11):1649~1671
2020- 2018 National Survey on Suicide South Korea Ministry of Health and Welfare
Talia L. Brown / 2018 / Access to Psychotropic Medication via Prescription Is Associated With Choice of Psychotropic Medication as Suicide Method / The Journal of Clinical Psychiatry 79(6)
Pentti M. Rautaharju / 2009 / AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram / Circulation 119(10):241~250
Peter M. Haddad / 2002 / Antipsychotic-Related QTc Prolongation, Torsade de Pointes and Sudden Death / Drugs 62(11):1649~1671
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