지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 182 - 188 (7page)
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초록· 키워드
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Objectives: Drug-induced QT prolongation can lead to life-threatening arrhythmia. In the intensive care unit (ICU), various drugs are administered concurrently, which can increase the risk of QT prolongation. However, no well-validated method to evaluate the risk of QT prolongation in real-world clinical practice has been established. We developed a risk scoring model to continuously evaluate the quantitative risk of QT prolongation in real-world clinical practice in the ICU. Methods: Continuous electrocardiogram (ECG) signals measured by patient monitoring devices and Electronic Medical Records data were collected for ICU patients. QT and RR intervals were measured from raw ECG data, and a corrected QT interval (QTc) was calculated by Bazett’s formula. A case-crossover study design was adopted. A case was defined as an occurrence of QT prolongation ≥12 hours after any previous QT prolongation. The patients served as their own controls. Conditional logistic regression was conducted to analyze prescription, surgical history, and laboratory test data. Based on the regression analysis, a QTc prolongation risk scoring model was established. Results: In total, 811 ICU patients who experienced QT prolongation were included in this study. Prescription information for 13 drugs was included in the risk scoring model. In the validation dataset, the high-risk group showed a higher rate of QT prolongation than the low-and low moderate-risk groups. Conclusions: Our proposed model may facilitate risk stratification for QT prolongation during ICU care as well as the selection of appropriate drugs to prevent QT prolongation.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Pickham D / 2012 / High prevalence of corrected QT interval prolongation in acutely ill patients is associated with mortality : results of the QT in Practice(QTIP)Study / Crit Care Med 40:394~399
Etchegoyen CV / 2017 / Drug-induced QT interval prolongation in the intensive care unit / Curr Clin Pharmacol 12:210~222
Beitland S / 2014 / Drug-induced long QT syndrome and fatal arrhythmias in the intensive care unit / Acta Anaesthesiol Scand 58:266~272
George TK / 2015 / Association between a prolonged corrected QT interval and outcomes in patients in a medical Intensive Care Unit / Indian J Crit Care Med 19:326~332
Fernandes FM / 2018 / QTc interval prolongation in critically ill patients : prevalence, risk factors and associated medications / PLoS One 13:e0199028
Etchegoyen CV / 2017 / Drug-induced QT interval prolongation in the intensive care unit / Curr Clin Pharmacol 12:210~222
Beitland S / 2014 / Drug-induced long QT syndrome and fatal arrhythmias in the intensive care unit / Acta Anaesthesiol Scand 58:266~272
George TK / 2015 / Association between a prolonged corrected QT interval and outcomes in patients in a medical Intensive Care Unit / Indian J Crit Care Med 19:326~332
Fernandes FM / 2018 / QTc interval prolongation in critically ill patients : prevalence, risk factors and associated medications / PLoS One 13:e0199028
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