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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 663 - 670 (8page)
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Background: Atelocollagen is widely recognized as a biomaterial for regenerative medicine because of its good compatibility and low antigenicity. Injury of the outermost layer of articular cartilage, known as the lamina splendens, can lead to osteoarthritis (OA) and eventually full-thickness cartilage loss. The intra-articular injection of atelocollagen has been designed to restore the cartilage layer and cartilage defects in OA joints. In this study, we investigated the efficacy of atelocollagen as a cartilage supplement for joint defects. Methods: In this study, we evaluated the therapeutic effects of atelocollagen in animals with cartilage defects. Femoral groove defects were artificially created in 12 male New Zealand white rabbits, which were treated with intra-articular injection of either atelocollagen (experimental) or normal saline (control). The results were observed 3, 6, 9, and 12 weeks following macroscopic and histological evaluations. Results: At 3 weeks, cartilage tissue was restored in the experimental group, whereas the control group did not show signs of restoration. At 12 weeks, defects in both groups were filled with regenerated tissue, but the experimental group displayed a morphologically better appearance. Histologically, the regenerated tissue in the experimental group showed statistically significant improvement compared to the control group, with a structure similar to that of normal articular cartilage. Conclusion: The results showed that the intra-articular injection of atelocollagen enhanced cartilage regeneration following rabbit patellar groove defects. Therefore, intra-articular injection of atelocollagen can be used as an effective supplement for joint defects.
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참고문헌 (29)
참고문헌 신청
Glowacki J / 2008 / Collagen scaffolds for tissue engineering / Biopolymers 89:338~344
Cornwell KG / 2009 / Extracellular matrix biomaterials for soft tissue repair / Clin Podiatr Med Surg 26:507~523
Owen RJ / 2012 / A preclinical study of the safety and efficacy of occlusin 500 artificial embolization device in sheep / Cardiovasc Intervent Radiol 35:636~644
Hughes LC / 2005 / The ultrastructure of mouse articular cartilage: collagen orientation and implications for tissue functionality. A polarised light and scanning electron microscope Studt and review / Eur Cell Mater 9:68~84
Poole CA / 1984 / Morphological and functional interrelationships of articular cartilage matrices / J Anat 138:113~138
Cornwell KG / 2009 / Extracellular matrix biomaterials for soft tissue repair / Clin Podiatr Med Surg 26:507~523
Owen RJ / 2012 / A preclinical study of the safety and efficacy of occlusin 500 artificial embolization device in sheep / Cardiovasc Intervent Radiol 35:636~644
Hughes LC / 2005 / The ultrastructure of mouse articular cartilage: collagen orientation and implications for tissue functionality. A polarised light and scanning electron microscope Studt and review / Eur Cell Mater 9:68~84
Poole CA / 1984 / Morphological and functional interrelationships of articular cartilage matrices / J Anat 138:113~138
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