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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 222 - 233 (12page)
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Impaired β-cell function is the key pathophysiology of type 2 diabetes mellitus, and chronic exposure of nutrient excess could lead to this tragedy. For preserving β-cell function, it is essential to understand the cause and mechanisms about the progression of β-cells failure. Glucotoxicity, lipotoxicity, and glucolipotoxicity have been suggested to be a major cause of β-cell dysfunction for decades, but not yet fully understood. Fatty acid translocase cluster determinant 36 (CD36), which is part of the free fatty acid (FFA) transporter system, has been identified in several tissues such as muscle, liver, and insulin-producing cells. Several studies have reported that induction of CD36 increases uptake of FFA in several cells, suggesting the functional interplay between glucose and FFA in terms of insulin secretion and oxidative metabolism. However, we do not currently know the regulating mechanism and physiological role of CD36 on glucolipotoxicity in pancreatic β-cells. Also, the downstream and upstream targets of CD36 related signaling have not been defined. In the present review, we will focus on the expression and function of CD36 related signaling in the pancreatic β-cells in response to hyperglycemia and hyperlipidemia (ceramide) along with the clinical studies on the association between CD36 and metabolic disorders.
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참고문헌 (90)
참고문헌 신청
김보연 / 2019 / Diabetes Fact Sheets in Korea, 2018: An Appraisal of Current Status / Diabetes and Metabolism Journal 43(4):487~494
Schwartz SS / 2016 / The time is right for a new classification system for diabetes : rationale and implications of the β-cell-centric classification schema / Diabetes Care 39:179~186
Abumrad NA / 1993 / Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation : homology with human CD36 / J Biol Chem 268:17665~17668
Armesilla AL / 1994 / Structural organization of the gene for human CD36 glycoprotein / J Biol Chem 269:18985~18991
Puente Navazo MD / 1996 / Identification on human CD36 of a domain(155-183)implicated in binding oxidized low-density lipoproteins(Ox-LDL) / Arterioscler Thromb Vasc Biol 16:1033~1039
Schwartz SS / 2016 / The time is right for a new classification system for diabetes : rationale and implications of the β-cell-centric classification schema / Diabetes Care 39:179~186
Abumrad NA / 1993 / Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation : homology with human CD36 / J Biol Chem 268:17665~17668
Armesilla AL / 1994 / Structural organization of the gene for human CD36 glycoprotein / J Biol Chem 269:18985~18991
Puente Navazo MD / 1996 / Identification on human CD36 of a domain(155-183)implicated in binding oxidized low-density lipoproteins(Ox-LDL) / Arterioscler Thromb Vasc Biol 16:1033~1039
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