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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 303 - 315 (13page)
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Background: The increase in circulating free fatty acid (FFA) levels is a major factor that induces malfunction in pancreatic β-cells. We evaluated the effect of FFAs reconstituted according to the profile of circulating fatty acids found in obese adolescents on the viability and function of the murine insulinoma cell line (mouse insulinoma [MIN6]). Methods: From fatty acids obtained commercially, plasma-FFA profiles of three different youth populations were reconstituted: obese with metabolic syndrome; obese without metabolic syndrome; and normal weight without metabolic syndrome. MIN6 cells were treated for 24 or 48 hours with the three FFA profiles, and glucose-stimulated insulin secretion, cell viability, mitochondrial function and antioxidant activity were evaluated. Results: The high FFA content and high polyunsaturated ω6/ω3 ratio, present in plasma of obese adolescents with metabolic syndrome had a toxic effect on MIN6 cell viability and function, increasing oxidative stress and decreasing glucose-dependent insulin secretion. Conclusion: These results could help to guide nutritional management of obese young individuals, encouraging the increase of ω-3-rich food consumption in order to reduce the likelihood of deterioration of β-cells and the possible development of type 2 diabetes mellitus.
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참고문헌 (39)
참고문헌 신청
NCD Risk Factor Collaboration (NCD-RisC) / 2016 / Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants / Lancet 387:1377~1396
Must A / 1999 / The disease burden associated with overweight and obesity / JAMA 282:1523~1529
Mokdad AH / 2003 / Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001 / JAMA 289:76~79
Despres JP / 2006 / Abdominal obesity and metabolic syndrome / Nature 444:881~887
Hotamisligil GS / 2006 / Inflammation and metabolic disorders / Nature 444:860~867
Must A / 1999 / The disease burden associated with overweight and obesity / JAMA 282:1523~1529
Mokdad AH / 2003 / Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001 / JAMA 289:76~79
Despres JP / 2006 / Abdominal obesity and metabolic syndrome / Nature 444:881~887
Hotamisligil GS / 2006 / Inflammation and metabolic disorders / Nature 444:860~867
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